Results 41 to 50 of about 159,394 (277)

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Characterization of enterotoxin, antibiotic resistance genes, and antimicrobial susceptibility profiling of Staphylococcus aureus isolated from table eggs: Implications for food safety and public health

Open Veterinary Journal
Background: Staphylococcus aureus is a significant pathogen in both clinical and food safety contexts, capable of contaminating table eggs, which are a common dietary staple worldwide.
Palash Bose, Kazi Abdus Sobur, Md. Bakhtiar Lijon, Md. Zaminur Rahman, Tanvir Ahamed, Papia Sultana, Muhammad Muktaruzzaman, Mst. Minara Khatun, Md. Ariful Islam   +8 more
doaj   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Evaluation of the Frequency of the Uropathogenic Escherichia coli Genotypes Resistant to Multidrug using the iucA, iucB, iucC, and iucD Siderophore Genes

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Urinary tract infection is one of the most common bacterial infections in humans, and Escherichia coli is one of the most important factors. Therefore, the present study aimed to evaluate the diversity of Europathogenic E.
Reihaneh Abroshan, Marjan Shaheli
doaj  

Magneto‐Sono‐Enhanced Nanozyme Catalysis Drives ROS‐Mediated Pathogen Killing and Mitophagy‐Linked Inflammation Control in Bacterial Pneumonia

Advanced Science, EarlyView.
Nebulized BN@NF nanozymes integrate boron nanosheets with Nd‐doped iron phosphide to form a sono‐magneto‐responsive Z‐scheme heterostructure. Under ultrasound and magnetic activation, BN@NF amplifies ROS generation, eradicates bacteria, disrupts biofilms, and reshapes pulmonary inflammation through NF‐κB suppression, mitophagy promotion, and M1‐to‐M2 ...
Xiaofeng Luo, Yundi Wu, Shuai Zhang, Huanran Qu, Shiyang Shao, Jianqiang Chen, Xilong Wu   +6 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Molecular detection of blaSHV gene in multidrug resistance of Klebsiella pneumoniae isolated from chicken egg shell swab from a traditional market in Surabaya

Open Veterinary Journal
Background: Contamination with Klebsiella pneumoniae in food ingredients, including eggs, causes various dangers because it threatens public health, because it acts as a multidrug resistance (MDR) bacteria, especially the extendedspectrum beta-lactamase
Azhari Athaillah Sulaiman, Mustofa Helmi Effendi, Leonardo Reza Srimaryanto, Aswin Rafif Khairullah, Pitaloka Kurniasari, Wiwiek Tyasningsih, Ikechukwu Benjamin Moses, Riza Zainuddin Ahmad, Saifur Rehman, Budiastuti Budiastuti, Daniah Ashri Afnani, Sheila Marty Yanestria, Katty Hendriana Priscilia Riwu, Agus Widodo   +13 more
doaj   +1 more source

Non-clinical isolates as potential reservoirs of antibiotic resistance in Port Harcourt, Nigeria

The Pan African Medical Journal, 2018
INTRODUCTION: Multidrug resistance (MDR) is a growing problem worldwide. This type resistance often arises due to the sequential acquisition of drug resistance determinants and subsequent clonal spread.
Kome Otokunefor, Paul Agbude, Tosanwumi Vincent Otokunefor   +2 more
doaj   +1 more source

Brain Network Dynamics of Local and Global Predictive Processing in Aging

Advanced Science, EarlyView.
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen, Gemma Fernández‐Rubio, David R. Quiroga‐Martinez, Mattia Rosso, Mathias Klarlund, Kit Melissa Larsen, Hartwig Roman Siebner, Morten L. Kringelbach, Peter Vuust, Leonardo Bonetti   +9 more
wiley   +1 more source

Short-Course Chemotherapy Regimens for Treatment of Multiple and Pre-Extensive Drug Resistant Tuberculosis in Combination with Surgery in Older Children and Adolescents

Туберкулез и болезни лёгких
The objective: to evaluate the effectiveness of short-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents.Subjects and Methods.
E. S. Ovsyankina, L. V. Panova, E. A. Krushinskaya, M. A. Bagirov   +3 more
doaj   +1 more source