Results 51 to 60 of about 100,852 (218)

High Rates of Aminoglycoside Methyltransferases Associated with Metallo-Beta-Lactamases in Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolates from a Tertiary Care Hospital in Egypt

Infection and Drug Resistance, 2021
Amira El-Far,1 Safia Samir,2 Eman El-Gebaly,3,4 Maysa Omar,1 Heba Dahroug,1 Ahmed El-Shenawy,1 Noha Salah Soliman,5 Doaa Gamal1 1Microbiology Department, Theodor Bilharz Research Institute (TBRI), Cairo, Egypt; 2Biochemistry and Molecular Biology ...
El-Far A, Samir S, El-Gebaly E, Omar M, Dahroug H, El-Shenawy A, Soliman NS, Gamal D   +7 more
doaj  

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, EarlyView.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Comparative Analysis of Uropathogenic Escherichia coli ST131 and Non-ST131 Isolated from Urinary Tract Infection Patients in Daejeon

Korean Journal of Clinical Laboratory Science, 2020
Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infections (UTIs), which is one of the most common infectious diseases in humans worldwide.
Hye Hyun Cho
doaj   +1 more source

From Double Materiality to Performance: Conceptualizing Reporting Under the European Sustainability Reporting Standards

Business Strategy and the Environment, EarlyView.
ABSTRACT As social and environmental challenges intensify, the EU has introduced the Corporate Sustainability Reporting Directive (CSRD), mandating sustainability reporting through the European Sustainability Reporting Standards (ESRS). The standards mandate a double materiality assessment but leave uncertainty about the structure and contents of the ...
Jørgen Kjøsen Lindgren, Nora Johanne Klungseth, Bjørn Sørskot Andersen   +2 more
wiley   +1 more source

Pharmaceutical properties for green fabricated ZnO and Ag nanoparticle-mediated Borago officinalis: In silico predications study

Green Processing and Synthesis
In this study, Borago officinalis flower extract was performed for green synthesis of silver nanoparticles (AgNPs) and Zinc Oxide (ZnONPs). The plant extract played essential roles as a stabilising and reducing agent.
Alkhafaji Alyaa A., Ahmed Hind M., Fadhil Yasir B., Allos Mina M., Jabir Majid S., Ahmed Duha S., Issa Ali Abdullah, Kong Kin Weng, Lau Beng Fye, Ghotekar Suresh, Swelum Ayman A.   +10 more
doaj   +1 more source

Bacterial Infections and Inflammatory Markers in Diabetic Foot Ulcers: Assessing the Roles of Staphylococcus aureus, Pseudomonas aeruginosa, Vascular Endothelial Growth Factor, and Interleukin-6

Medical Journal of Babylon
Background:Diabetic foot ulcers (DFUs) are severe complications of diabetes, leading to osteomyelitis, gangrene, and limb amputation. These outcomes increase mortality risk and bacterial resistance in surviving patients.
Sarah Kadhim Abbas, Dakhel Ghani Omran, Lubna Abdulazeem   +2 more
doaj   +1 more source

Distribution of mcr-1 Harboring Hypervirulent Klebsiella pneumoniae in Clinical Specimens and Lytic Activity of Bacteriophage KpnM Against Isolates

Infection and Drug Resistance, 2022
Bilal Aslam,1 Muhammad Hussnain Siddique,2 Abu Baker Siddique,1 Muhammad Shafique,1 Saima Muzammil,1 Mohsin Khurshid,1 Muhammad Hidayat Rasool,1 Moeed Ahmad,1 Tamoor Hamid Chaudhry,3 Afreenish Amir,3 Muhammad Salman,3 Zulqarnain Baloch,4 Norah A Alturki ...
Aslam B, Siddique MH, Siddique AB, Shafique M, Muzammil S, Khurshid M, Rasool MH, Ahmad M, Chaudhry TH, Amir A, Salman M, Baloch Z, Alturki NA, Alzamami A   +13 more
doaj  

ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF METHICILLIN RESISTANT AND METHICILLIN SENSITIVE STAPHYLOCOCCUS AUREUS FROM BOVINE MILK IN THE STATE OF HARYANA, INDIA [PDF]

Exploratory Animal and Medical Research
Bovine mastitis is the principal leading cause of monetary losses to dairy farmers. This disease impacts the udder health as well as the quantitative and qualitative parameters of milk.
Jasleen Kaur, Anshul Lather, Sarin Kamboj, Mahavir Singh, Jinu Manoj, Rajesh Chhabra   +5 more
doaj   +1 more source

Video‐based diagnostics supported by artificial intelligence as an opportunity to address the epilepsy diagnostic gap: A narrative review

Epilepsia, EarlyView.
Abstract Despite advancements in epilepsy care, a substantial diagnostic gap persists, particularly in resource‐limited settings. This narrative review explores the potential of video‐based diagnostics augmented by artificial intelligence (AI) to address this gap by enabling earlier and more accessible seizure detection and classification.
Gadi Miron, Robert Terziev, Maximilian Schöls, John McLaren, Tobias Loddenkemper, Jörg Wellmer, Sigrid Mues, Christian Meisel   +7 more
wiley   +1 more source