Results 71 to 80 of about 100,852 (218)

Should Dermatologists Recommend Direct‐to‐Consumer App‐Based Remote Diagnostics? An Ethical Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Dermatology patients still face barriers in accessing timely specialist care. As direct‐to‐consumer (DTC) apps for remote dermatological diagnostics proliferate, guidance is lacking. While promising efficiency and efficacy, their clinical—and ethical—legitimacy is not yet well established.
Sonja Mathes, Sebastian Seurig, Theresa Willem, Marta Dechant, Stephan Traidl, Mina Kang, Pedro Marques Pinto, Annette Binder, Tilo Biedermann, Ulf Darsow   +9 more
wiley   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Prevailing Antibiotic Resistance Patterns in Hospitalized Patients with Urinary Tract Infections in a Vietnamese Teaching Hospital (2014 – 2021)

Infection and Drug Resistance
Hai Ha Long Le,1,2 Luong Cong Thuc,3 Thang Ba Ta,4 Tien Viet Tran,5 Dinh Viet Hung,6 Hoang Trung Kien,7 Minh Nhat Le,8,9 Vu Huy Luong,10,11 Vinh Thi Ha Nguyen,11,12 Hoa Quynh Pham,13 Hung Van Le,11,13 Nguyen Hoang Viet,14 Le Huy Hoang,15 Tram Thuy Nguyen,
Le HHL, Thuc LC, Ta TB, Tran TV, Hung DV, Kien HT, Le MN, Luong VH, Nguyen VTH, Pham HQ, Le HV, Viet NH, Hoang LH, Nguyen TT, Latsavong M, Le TD, Trong Tuan D, An NV   +17 more
doaj  

Uncovering Key Characteristics of Antibacterial Peptides through Machine Learning

Macromolecular Rapid Communications, EarlyView.
Machine‐learning (ML) techniques using random forest classification models revealed key characteristics that predict effective antimicrobial peptides (AMPs) targeting Gram‐negative bacteria, Gram‐positive bacteria, and mycobacteria. The ideal cLogP (<$ < $−6) and net‐charge (≤+4) threshold was the same for all three targets with variations in the ...
Jooyoung Roh, Cyrille Boyer, Priyank V. Kumar   +2 more
wiley   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Clinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity. Objectives To provide an updated
Evita Papathoma, Panagiota Tsitsi, Nirosen Vijiaratnam, Camila Aquino, Stephen R. Duma, Norbert Kovacs, Kigocha Lameck Okeng'o, Aparna Wagle Shukla, Roongroj Bhidayasiri, Tiago A. Mestre, Alvaro Sanchez Ferro, Alberto J. Espay, Michelle H.S. Tosin, Matej Skorvanek, Ioanna Markaki   +14 more
wiley   +1 more source

Coping Behavior in Patients with Parkinson's Disease Prior to Subthalamic Deep Brain Stimulation and Association with Psychiatric Symptoms, Quality of Life and Neuropsychological Status

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Coping behavior of Parkinson's disease (PD) patients undergoing subthalamic Deep Brain Stimulation (STN‐DBS) is poorly understood. Identifying patients with ineffective coping could help prepare them better for surgery. Objectives To clarify coping of PD patients preoperatively and the relation with psychiatric symptoms, quality of ...
Roy Brian Kuiper, Victor Jacobus Geraedts, Niels Anthony van der Gaag, Carel Frederik Ernst Hoffmann, Esther Lauwen, Rodi Zutt, Dirk Adrianus van der Zwart, Hubertus Anthonius Maria Middelkoop, Maria Fiorella Contarino   +8 more
wiley   +1 more source

An In vitro Analysis of the Efficacy of Saudi Clover and Talh Honey on Bacterial Resistance to Antibiotics and Biofilm Formation

Journal of Pure and Applied Microbiology
The emergence of multidrug-resistant bacteria presents a significant global health risk, necessitating the exploration of alternative treatment options.
Wafaa Alhazmi, Hashem Felemban, Ahmad Sait, Khalid Almuntashiri, Ali Alqahtani, Amjad Turkistani, Rayyan Alzahrani, Ammar Basabrain   +7 more
doaj   +1 more source

Subthalamic Nucleus Deep Brain Stimulation Improves Kinetic Tremor in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Although resting tremor is a characteristic feature of Parkinson's disease (PD), many patients also suffer from action tremor. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective in reducing motor symptoms. However, it is unclear to what extent STN‐DBS improves action tremor in PD, particularly kinetic tremor.
Iwan Grooters, Bart E.K.S. Swinnen, Yarit Wiggerts, Maarten Bot, Pepijn van den Munckhof, P. Rick Schuurman, Martijn Beudel, Rob M.A. de Bie, Arthur W.G. Buijink   +8 more
wiley   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source