Results 1 to 10 of about 24,528 (176)

First report of Serotype-1 Marek’s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study

BMC Veterinary Research, 2022
Background Marek’s disease (MD) is a lymphoproliferative disease caused by Gallid alphaherpesvirus 2 (GaHV-2, MDV-1), which primarily affects chickens. However, the virus is also able to induce tumors and polyneuritis in turkeys, albeit less frequently ...
Hasan Ongor, Necati Timurkaan, Hasan Abayli, Burak Karabulut, Hakan Kalender, Sukru Tonbak, Hatice Eroksuz, Burhan Çetinkaya   +7 more
doaj   +2 more sources

The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes [PDF]

Viruses, 2019
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and poses a serious threat to poultry health. In infected animals, MDV efficiently replicates in B cells in various lymphoid organs.
Luca D. Bertzbach, Florian Pfaff, Viktoria I. Pauker, Ahmed M. Kheimar, Dirk Höper, Sonja Härtle, Axel Karger, Benedikt B. Kaufer   +7 more
doaj   +4 more sources

Structural characteristics and antiviral activity of multiple peptides derived from MDV glycoproteins B and H

Virology Journal, 2011
Background Marek's disease virus (MDV), which is widely considered to be a natural model of virus-induced lymphoma, has the potential to cause tremendous losses in the poultry industry.
Wang Ming, Chi Xiaojing, Wang Xiaojia
doaj   +2 more sources

Amino acid insertion in the Meq protein of Marek’s disease virus, an avian oncogenic herpesvirus, accelerates tumorigenesis [PDF]

Microbiology Spectrum
Marek’s disease virus (MDV) causes lymphomas (Marek’s disease) in chickens. Despite vaccination, MDV field strains exhibit increased virulence, and sporadic outbreaks are still reported.
Jumpei Sato, Shiro Murata, Yoshinosuke Motai, Shwe Yee Win, Hikari Seo, Shunsuke Yamagami, Naoya Maekawa, Tomohiro Okagawa, Satoru Konnai, Kazuhiko Ohashi   +9 more
doaj   +2 more sources

Pathogenicity and Pathotype Analysis of Henan Isolates of Marek’s Disease Virus Reveal Long-Term Circulation of Highly Virulent MDV Variant in China

Viruses, 2022
In recent years, outbreaks of Marek’s disease (MD) have been frequently reported in vaccinated chicken flocks in China. Herein, we have demonstrated that four Marek’s disease virus (MDV) isolates, HN502, HN302, HN304, and HN101, are all pathogenic and ...
M. Teng, Luping Zheng, Hui-zhen Li, Sheng-Ming Ma, Zhi-jian Zhu, S. Chai, Yongxiu Yao, V. Nair, Gai-ping Zhang, Jun Luo   +9 more
semanticscholar   +1 more source

Differential Replication and Cytokine Response between Vaccine and Very Virulent Marek’s Disease Viruses in Spleens and Bursas during Latency and Reactivation

Viruses, 2022
Marek’s disease virus (MDV) infection results in Marek’s disease (MD) in chickens, a lymphoproliferative and oncogenic deadly disease, leading to severe economic losses. The spleen and bursa are the most important lymphoid and major target organs for MDV
Bo Jiang, Jing Wang, Mengyao Cao, Huan Jin, Wenxiao Liu, Jing Cheng, Linyi Zhou, Jian Xu, Yongqing Li   +8 more
doaj   +1 more source

U_S3 Serine/Threonine Protein Kinase from MDV-1, MDV-2, and HVT Differentially Regulate Viral Gene Expression and Replication

Microorganisms, 2021
Gallid alphaherpesvirus 2 (GaHV-2), commonly known as Marek’s disease virus type 1 (MDV-1), is an oncogenic avian alphaherpesvirus, and along with its close relatives—Gallid alphaherpesvirus 3 (GaHV-3) or MDV-2 and Meleagrid alphaherpesvirus 1 (MeHV-1 ...
Yifei Liao, Xin Fang, Mohammad AI-Mahmood, Qinglei Li, Blanca Lupiani, Sanjay M. Reddy   +5 more
doaj   +1 more source

RIOK3-Mediated Akt phosphorylation facilitates synergistic replication of Marek’s disease and reticuloendotheliosis viruses

Virulence, 2022
Co-infection of Marek’s disease virus (MDV) and reticuloendotheliosis virus (REV) synergistically drives disease progression, yet little is known about the mechanism of the synergism.
Xusheng Du, Defang Zhou, Jing Zhou, Jingwen Xue, Ziqiang Cheng   +4 more
doaj   +1 more source

Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis.

PLoS Pathogens, 2021
Marek's disease virus (MDV) is a potent oncogenic alphaherpesvirus that elicits a rapid onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV-1), GaHV-3 (MDV-2) and MeHV-1 (HVT), have been identified and all encode a US3
Yifei Liao, Blanca Lupiani, Mohammad Ai-Mahmood, Sanjay M Reddy   +3 more
doaj   +1 more source

Latest Insights into Unique Open Reading Frames Encoded by Unique Long (UL) and Short (US) Regions of Marek’s Disease Virus

Viruses, 2021
Marek’s disease virus (MDV) is an oncogenic avian alphaherpesvirus whose genome consists of unique long (UL) and short (US) regions that are flanked by inverted repeat regions.
Yifei Liao, Blanca Lupiani, Sanjay M. Reddy   +2 more
doaj   +1 more source