Results 101 to 110 of about 265,786 (329)

Mean curvature flow of Reifenberg sets [PDF]

Geometry & Topology, 2017
In this paper, we prove short time existence and uniqueness of smooth evolution by mean curvature in $\mathbb{R}^{n+1}$ starting from any $n$-dimensional $(\varepsilon,R)$-Reifenberg flat set with $\varepsilon$ sufficiently small. More precisely, we show that the level set flow in such a situation is non-fattening and smooth.
openaire   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Non-local interaction in discrete Ricci curvature-induced biological aggregation

Royal Society Open Science
We investigate the collective dynamics of multi-agent systems in two- and three-dimensional environments generated by minimizing discrete Ricci curvature with local and non-local interaction neighbourhoods.
Jyotiranjan Beuria, Laxmidhar Behera
doaj   +1 more source

Local Well-Posedness of Skew Mean Curvature Flow for Small Data in d ≥ 4 Dimensions. [PDF]

Commun Math Phys, 2022
Huang J, Tataru D.
europepmc   +1 more source

Long time behavior of discrete volume preserving mean curvature flows

, 2022
Massimiliano Morini, Marcello Ponsiglione, Emanuele Spadaro   +2 more
openalex   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

Frontiers in Physiology
Objective: The aim of this study is to perform specific hemodynamic simulations of idealized abdominal aortic aneurysm (AAA) models with different diameters, curvatures and eccentricities and evaluate the risk of thrombosis and aneurysm rupture.Methods ...
Lulu Wang, Xudong Jiang, Kejia Zhang, Kai Chen, Peng Wu, Xiaoqiang Li   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Rigidity properties of Colding–Minicozzi entropies

Advanced Nonlinear Studies
We show certain rigidity for minimizers of generalized Colding–Minicozzi entropies. The proofs are elementary and work even in situations where the generalized entropies are not monotone along mean curvature flow.
Bernstein Jacob
doaj   +1 more source