Results 81 to 90 of about 39,604,900 (297)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Challenging the mean time to failure: Measuring dependability as a mean failure cost
, 2009 As a measure of system reliability, the mean time to failure falls short on many fronts: it ignores the variance in stakes among stakeholders; it fails to recognize the structure of complex specifications as the aggregate of overlapping requirements; it ...
Sheldon, Frederick, Mili, Ali
core +1 more source
Quick algorithms to calculate mean time to failure and steady state availability of systems
, 2012 Calculation of reliability and availability is a necessary part of every fault tolerant system design. Conventional methods, which use calculus of probability, almost fail when there is dependant failure, repair, or standby operation in the system.
Přenosil, Václav, Amiri, Moslem
core +3 more sources
, 2016 A significant percentage of production costs is the maintenance costs, and analysis of maintenance costs could to achieve greater productivity and competitiveness. With this is mind, the maintenance of machines and installations is considered as an essential part of organizational functions and applying effective strategies causes significant added ...
Jalal Soleimannejad +3 more
openaire +2 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Availability and mean time between failures of redundant systems with random maintenance of subsystems [PDF]
, 1977 It is shown how the availability and MTBF (Mean Time Between Failures) of a redundant system with subsystems maintenanced at the points of so-called stationary renewal processes can be determined from the distributions of the intervals between ...
Schneeweiss, W.
core
Study on Mean Time Between Failures Prediction Algorithms Based on Weibull Distribution
IOP Conference Series: Earth and Environmental Science, 2020 Abstract The system reliability is significant importance because it is involved into most stages of the whole life-cycle of product. According to the existing literature, MTBF is the most frequently used index to indicate the system reliability.
Peitong wang, Jinwei Fan, Zhongsheng Li
openaire +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
On the Limits of Greenwich Mean Time, or The Failure of a Modernist Revolution
, 2014 On the Limits of Greenwich Mean Time, or The Failure of a Modernist Revolution From the introduction of World Standard Time in 1884 to Einstein’s theory of relativity, the nature and regulation of time was a highly contested issue in modernism, with ...
Huber, Irmtraud
core