Results 191 to 200 of about 209,630 (263)

Existential suffering at the end of life in long-term care: A critical essay on recognition, dignity, and witness. [PDF]

Palliat Care Soc Pract
Romem A, Bardach R.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Qualitative research - Part 2 - Choosing a research design. [PDF]

Perspect Clin Res
Ravindran V, Hanebrink J, Graetz DE, Mathew A, Pramesh CS, Ranganathan P.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

East meets West: cross-cultural generalizability of the numinous motivation inventory in Poland and Vietnam. [PDF]

Front Psychol
Piedmont RL, Bochniarz KT, Fox J, Bui TT, Tran HT, Różycka-Tran J.   +5 more
europepmc   +1 more source

The case for decolonizing data sources in indigenous evaluation and research. [PDF]

Front Public Health
Kelley A.
europepmc   +1 more source

Spirituality as a coping resource: Towards integration into mental health framework. [PDF]

PLOS Ment Health
Nepali S.
europepmc   +1 more source

Beyond Static Career Stages: Further Considerations for Medication Safety Competence. [PDF]

Nurs Health Sci
Zhong Y.
europepmc   +1 more source