Results 91 to 100 of about 50,666 (264)

Blaming the Young Misses the Point: Re-assessing Young People’s Political Participation over Time Using the ‘Identity-equivalence Procedure’

Methoden, Daten, Analysen, 2018
One of the central and constantly recurring features of youth participation studies is the depiction of young people and adolescents as the future of democratic politics.
Christian Schnaudt, Michael Weinhardt
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Equivalent measures of dependence

Journal of Multivariate Analysis, 1983
AbstractThe maximal correlation between a pair of σ-fields A and B becomes arbitrarily small as sup{|P(A ⋔ B) − P(A) P(B)|/[P(A) P(B)]1/2, A ∈ A, B ∈ B, P(A) > 0, P(B) > 0} becomes sufficiently small.
openaire   +1 more source

Equivalent martingale measures and Lévy processes [PDF]

Revista Brasileira de Economia, 2006
Neste trabalho calculamos as medidas martingalas equivalentes quando os retornos dos precos dos ativos sao modelados por um Processo de Levy. Seguimos la formulacao introduzida por Gerber e Shiu (1994).
openaire   +5 more sources

Investigating measurement invariance in PIRLS 2021 across English and isiZulu language groups

Reading & Writing
Background: PIRLS 2021 results revealed that South African Grade 4 learners performed significantly lower compared to other countries in reading comprehension and that they did not reach the standardised international mean score of 500.
Sinethemba Mthimkhulu, Karen Roux, Maryke Mihai   +2 more
doaj   +1 more source

Development of an international survey attitude scale: measurement equivalence, reliability, and predictive validity

Measurement Instruments for the Social Sciences, 2019
Declining response rates worldwide have stimulated interest in understanding what may be influencing this decline and how it varies across countries and survey populations.
Edith de Leeuw, Joop Hox, Henning Silber, Bella Struminskaya, Corrie Vis   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source