Results 71 to 80 of about 48,611 (263)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Reference material comparisons: design of experiment and processing of measurement results
Стандартные образцы, 2017 The present article describes general principles of experimental research and processing of measurement results within the framework of one of the methods of evaluating the interchangeability of reference materials - paired comparisons of reference ...
E. V. Osintseva
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The applicability of low-cost PM10 sensors for atmospheric air quality monitoring
SHS Web of Conferences, 2018 Described in this work are the results of field tests carried out in the Tricity Agglomeration between 01 April 2018 and 30 June 2018 in order to evaluate the usefulness of low-cost PM10 sensors in atmospheric air quality monitoring.
Szulczyński Bartosz, Gębicki Jacek
doaj +1 more source
On Equivalence of Probability Measures
The Annals of Probability, 1973 Let $H$ be a real and separable Hilbert space, $\Gamma$ the Borel $\sigma$-field of $H$ sets, and $\mu_1$ and $\mu_2$ two probability measures on $(H, \Gamma)$. Several sufficient conditions for equivalence (mutual absolute continuity) of $\mu_1$ and $\mu_2$ are obtained in this paper.
openaire +3 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The Impact of Partial Measurement Invariance on Testing Moderation for Single and Multi-Level Data
Frontiers in Psychology, 2018 Moderation effect is a commonly used concept in the field of social and behavioral science. Several studies regarding the implication of moderation effects have been done; however, little is known about how partial measurement invariance influences the ...
Yu-Yu Hsiao, Mark H. C. Lai
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Psychometric Properties of the Chinese Version of the Neuroticism Subscale of the NEO-PI
Frontiers in Psychology, 2018 Neuroticism is an important concept in psychology, self-report measures of neuroticism are important for both research and clinical practice. The neuroticism subscale of the Neuroticism-Extraversion-Openness Personality Inventory (NEO-PI) is a brief ...
Chang Xi +10 more
doaj +1 more source