Results 221 to 230 of about 438,222 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. [PDF]

Sci Adv
Xu Y, Ying L, Lang JK, Hinz B, Zhao R.
europepmc   +1 more source

Study of the Influence of Sintering Atmosphere and Mechanical Activation on the Synthesis of Bulk Ti₂AlN MAX Phase Obtained by Spark Plasma Sintering. [PDF]

Materials (Basel), 2021
Salvo C, Chicardi E, García-Garrido C, Poyato R, Jiménez JA, Mangalaraja RV.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Polymer time crystal: Mechanical activation of reversible bonds by low-amplitude high frequency excitations. [PDF]

Sci Adv
Heidari M, Gaichies T, Leibler L, Labousse M.   +3 more
europepmc   +1 more source

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts. [PDF]

Cells, 2020
Godbout E, Son DO, Hume S, Boo S, Sarrazy V, Clément S, Kapus A, Wehrle-Haller B, Bruckner-Tuderman L, Has C, Hinz B.   +10 more
europepmc   +1 more source

Effect of Mechanical Activation of Al-Ti-B Powder Mixture on Phase Composition and Structure of Al-TiB₂ Composite Materials Obtained by Self-Propagating High-Temperature Synthesis (SHS). [PDF]

Materials (Basel), 2022
Matveev A, Promakhov V, Nikitin P, Babaev A, Vorozhtsov A.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

MULTIMODAL LEARNING TO IMPROVE CARDIAC LATE MECHANICAL ACTIVATION DETECTION FROM CINE MR IMAGES. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wu N, Bilchick KC, Epstein FH, Zhang M.   +4 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source