Results 221 to 230 of about 915,324 (354)

SCAR-AWARE LATE MECHANICAL ACTIVATION DETECTION NETWORK FOR OPTIMAL CARDIAC RESYNCHRONIZATION THERAPY PLANNING. [PDF]

Proc IEEE Int Symp Biomed Imaging
Xing J, Wang S, Patel AR, Bilchick KC, Epstein FH, Zhang M.   +5 more
europepmc   +1 more source

Mechanical activation of the angiotensin II type 1 receptor contributes to abdominal aortic aneurysm formation. [PDF]

JVS Vasc Sci, 2021
Hall S, Ward ND, Patel R, Amin-Javaheri A, Lanford H, Grespin RT, Couch C, Xiong Y, Mukherjee R, Jones JA, Ruddy JM.   +10 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface. [PDF]

Front Bioeng Biotechnol, 2020
Sianati S, Schroeter L, Richardson J, Tay A, Lamandé SR, Poole K.   +5 more
europepmc   +1 more source

Outcomes of Cardiac Resynchronization Therapy with Image-Guided Left Ventricular Lead Placement at the Site of Latest Mechanical Activation: A Systematic Review and Meta-Analysis. [PDF]

J Interv Cardiol, 2022
Allen LaPointe NM, Ali-Ahmed F, Dalgaard F, Kosinski AS, Schmidler GS, Al-Khatib SM.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Lab-Scale Evaluation of Parameters Influencing the Mechanical Activation of Kaolin Using the Design of Experiments. [PDF]

Materials (Basel)
Mañosa J, Alvarez-Coscojuela A, Maldonado-Alameda A, Chimenos JM.   +3 more
europepmc   +1 more source

Mechanical Activation of MscL Revealed by a Locally Distributed Tension Molecular Dynamics Approach. [PDF]

Biophys J, 2021
Rajeshwar T R, Anishkin A, Sukharev S, Vanegas JM.   +3 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source