Results 171 to 180 of about 4,432,927 (296)

Hydro-mechanical damage modeling of water-bearing sandstone using an energy dissipation approach under triaxial stress. [PDF]

Sci Rep
Liu Z, Du B, Zhu H, Jiang Y, Wang T, Chen W, Zhao Y, Wang Y.   +7 more
europepmc   +1 more source

Mechanical Damage Assessment for Pneumatic Control Valves Based on a Statistical Reliability Model. [PDF]

Sensors (Basel), 2021
Mathur N, Asirvadam VS, Aziz AA.
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Shear stress stimuli-induced erythrocytes' mechanical damage, and its relation to erythrocytes' membrane oxidation and cellular aging. [PDF]

J Clin Biochem Nutr
Watanabe N, Inoue M, Kato Y, Kubota R, Sakota D, Fukui K.   +5 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Identification of MsCYP79 and MsCYP83 gene families and its response to mechanical damage in Medicago sativa L. [PDF]

PLoS One
Wu F, Zhang J, Yang H, Duan H.
europepmc   +1 more source

A coupled thermo-mechanical damage model for fired clay bricks based on the unified strength theory. [PDF]

Heliyon, 2021
Mpoung LA, Bidoung JC, Sontia Metekong JV, Meva'a JRL.   +3 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of mechanical damage and viscoelasticity on aortas from guinea pigs subjected to hypoxia. [PDF]

Sci Rep
Bezmalinovic A, Navarrete Á, Latorre M, Celentano D, Herrera EA, García-Herrera C.   +5 more
europepmc   +1 more source

A source-sink model explains the difference in the metabolic mechanism of mechanical damage to young and senescing leaves in Catharanthus roseus. [PDF]

BMC Plant Biol, 2021
Chen Q, Lu X, Guo X, Xu M, Tang Z.
europepmc   +1 more source