Results 21 to 30 of about 110,588 (202)

Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

Micromachines, 2021
Organ-on-a-chip (OOC) uses the microfluidic 3D cell culture principle to reproduce organ- or tissue-level functionality at a small scale instead of replicating the entire human organ. This provides an alternative to animal models for drug development and
Qianbin Zhao, Tim Cole, Yuxin Zhang, Shi-Yang Tang   +3 more
doaj   +1 more source

Mechanical and metabolic interplay in the brain metastatic microenvironment

Frontiers in Oncology, 2022
In this Perspective, we provide our insights and opinions about the contribution—and potential co-regulation—of mechanics and metabolism in incurable breast cancer brain metastasis.
Killian Onwudiwe, Alice A. Burchett, Meenal Datta   +2 more
doaj   +1 more source

Conditioning the microenvironment for soft tissue regeneration in a cell free scaffold

Scientific Reports, 2021
The use of cell-free scaffolds for the regeneration of clinically relevant volumes of soft tissue has been challenged, particularly in the case of synthetic biomaterials, by the difficulty of reconciling the manufacturing and biological performance ...
Irini Gerges, Margherita Tamplenizza, Federico Martello, Stefano Koman, Giulia Chincarini, Camilla Recordati, Mariacaterina Tamplenizza, Scott Guelcher, Maurizio Crestani, Alessandro Tocchio   +9 more
doaj   +1 more source

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

Nature Communications, 2019
It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours.
Nicola Ferrari, Romana Ranftl, Ievgeniia Chicherova, Neil D. Slaven, Emad Moeendarbary, Aaron J. Farrugia, Maxine Lam, Maria Semiannikova, Marie C. W. Westergaard, Julia Tchou, Luca Magnani, Fernando Calvo   +11 more
doaj   +1 more source

Gradient mechanical environments modulate intra-osteonal fluid flow: a three-dimensional finite element study

Frontiers in Bioengineering and Biotechnology
ObjectiveInterstitial fluid flow within the osteonal lacunar-canalicular system (LCS) is crucial for osteocyte mechanotransduction and bone remodeling. This study aims to develop a three-dimensional finite element model of an osteon with gradient-varying
Yu Weilun, Yu Weilun, Feng Haoyu, Gao Xu, Huang Siting, Li Xinyao, Xie Lang, Liu Xiaoxi, Yang Xiaohang   +8 more
doaj   +1 more source

Microscale Interrogation of 3D Tissue Mechanics

Frontiers in Bioengineering and Biotechnology, 2019
Cells in vivo live in a complex microenvironment composed of the extracellular matrix (ECM) and other cells. Growing evidence suggests that the mechanical interaction between the cells and their microenvironment is of critical importance to their ...
Jian Zhang, Neil C. Chada, Cynthia A. Reinhart-King   +2 more
doaj   +1 more source

Modeling analysis of microenvironment of 3D cell mechanics based on machine vision

Open Physics, 2022
Aiming at the problem of poor construction accuracy of the cellular three-dimensional (3D) mechanical microenvironment, this article studies the cellular 3D mechanical microenvironment based on machine vision. The gelatin methacrylate microgel column was
Zhang Yuejin, Ye Mengqiu, Wang Juan, Li Guanghui, Zhong Meiling, Zhan Aiyun   +5 more
doaj   +1 more source

Mechanical Cues Regulate Histone Modifications and Cell Behavior

Stem Cells International, 2022
Change of biophysical factors in tissue microenvironment is an important step in a chronic disease development process. A mechanical and biochemical factor from cell living microniche can regulate cell epigenetic decoration and, therefore, further induce
Buwei Hu, Dandan Zhou, Haoming Wang, Ning Hu, Weikang Zhao   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Substrate Stiffness Modulates Hypertrophic Chondrocyte Reversion and Chondrogenic Phenotype Restoration

Cells
The stiffness of the extracellular matrix (ECM) plays a pivotal role in the progression of osteoarthritis (OA), particularly by promoting hypertrophic differentiation of chondrocytes, which hinders cartilage regeneration and accelerates pathological ...
Da-Long Dong, Guang-Zhen Jin
doaj   +1 more source