Results 91 to 100 of about 2,305,322 (279)

Tension mediated nonlinear coupling between orthogonal mechanical modes of nanowire resonators

, 2018
We study the nonlinear coupling between orthogonal flexural modes of doubly clamped InAs nanowire resonators. The two orthogonal modes are formed by the symmetry breaking and lifting of degeneracy of the fundamental mode.
Bhushan, Anand, Deshmukh, Mandar M., Mathew, John P.   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mechanical response characteristics and damage mechanism of water-containing mudstone under low strain rate dynamic loading

Meitan xuebao
Accelerated instability and failure of surrounding water-rich mudstone in roadway under dynamic loading has become a prominent problem in deep coal resource mining, and it is of great significance to study the damage mechanism of water-containing ...
Guichen LI, Sen YANG, Yuantian SUN, Jinghua LI, Haoran HAO, Zeyu SHAO   +5 more
doaj   +1 more source

A 3D Discrete-Continuum Coupling Approach for Investigating the Deformation and Failure Mechanism of Tunnels across an Active Fault: A Case Study of Xianglushan Tunnel

Applied Sciences, 2019
For water transmission tunnels constructed in high-risk seismic regions of western China, active faults pose threats of serious ruptures to the tunnels. To overcome this issue, a 3D discrete-continuum coupling approach is introduced into the study.
Yalina Ma, Qian Sheng, Guimin Zhang, Zhen Cui   +3 more
doaj   +1 more source

Item response mechanics

, 2021
Statistical models for the relations between variables encompass assumptions about the underlying mechanism that generated the relations in the observed data. This dissertation introduces item response mechanics as the study of data-generating mechanisms underlying an item response, and their implementation in psychometric process-measurement models.
openaire   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Response evolution of mechanical metamaterials under architectural transformations

New Journal of Physics, 2020
Architectural transformations play a key role in the evolution of complex systems, from design algorithms for metamaterials to flow and plasticity of disordered media.
A S Meeussen, E C Oğuz, M van Hecke, Y Shokef   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Atom-mirror cooling and entanglement using cavity Electromagnetically Induced Transparency

, 2011
We investigate a hybrid optomechanical system comprised of a mechanical oscillator and an atomic 3-level ensemble within an optical cavity. We show that a suitably tailored cavity field response via Electromagnetically Induced Transparency (EIT) in the ...
Aurélien Dantan, C. W. Gardiner, Claudiu Genes, Helmut Ritsch, M. A. Nielsen, Michael Drewsen   +5 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source