Results 121 to 130 of about 2,305,322 (279)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mechanical response mechanism and temporary support for unsupported roof area in coal roadway excavation

矿业科学学报
This study investigates the mechanical response mechanism and temporary support method of surrounding rock in coal mines under varying unsupported roof distances, with 9103 transportation roadway of Wangzhuang coal mine taken as a case study.
HAO Wenhua, WANG Fangtian, WU Peilin, YIN Zhihua, TANG Tiankuo, LIU Chao, WU Yu   +6 more
doaj   +1 more source

Mechanically Responsive Molecular Crystals

Chemical Reviews, 2015
Panče, Naumov, Stanislav, Chizhik, Manas K, Panda, Naba K, Nath, Elena, Boldyreva   +4 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Model Test of Mechanical Response of Negative Poisson’s Ratio Anchor Cable in Rainfall-Induced Landslides

Buildings
Rainfall-induced landslide mitigation remains a critical research focus in geotechnical engineering, particularly for safeguarding buildings and infrastructure in unstable terrain.
Guangcheng Shi, Zhigang Tao, Feifei Zhao, Jie Dong, Xiaojie Yang, Zhouchao Xu, Xiaochuan Hu   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Study on in-situ mechanical response and energy evolution law of water-immersed mudstone

Meikuang Anquan
To investigate the mechanical properties and energy evolution mechanism of water-immersed mudstone under complex in-situ stress conditions, we selected the floor mudstone in Yitang Coal Mine as the research object and conducted triaxial compression tests
Chenhong PAN, Xiaoqiang ZHANG, Yulong JIANG, Kai WANG, Jian HOU, Jixin CHEN, Wenwei WANG   +6 more
doaj   +1 more source

A study of the relationships between the mechanical response of the tympanic membrane and the electrophysiological indicators of hearing in the bullfrog (Rana catesbeiana) [PDF]

Mechanical response of frog membrane to stimulating frequencies and electrophysiologically determined hearing ...
Majeau-Chargois, D. A., Whitehead, J. M.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source