Results 21 to 30 of about 3,260,986 (243)

The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone

, 2006
It has been shown previously using in vivo and ex vivo animal models, that cyclical mechanical stimulation is capable of maintaining osteocyte viability through the control of apoptotic cell death.
Noble, B., Kogianni, G., Mann, V., Huber, C., Jones, D.   +4 more
core   +3 more sources

Low-magnitude high-frequency vibration enhanced mesenchymal stem cell recruitment in osteoporotic fracture healing through the SDF-1/CXCR4 pathway [PDF]

European Cells & Materials, 2016
Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic fracture healing. Mechanical stimulation was reported to enhance SDF-1/CXCR4 signalling in mesenchymal stem cells (MSCs).
F-Y Wei, SK Chow, K-S Leung, J Qin, A Guo, OL Yu, G Li, W-H Cheung   +7 more
doaj   +1 more source

Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling

eLife, 2022
Proper mechanical stimulation can improve rotator cuff enthesis injury repair. However, the underlying mechanism of mechanical stimulation promoting injury repair is still unknown. In this study, we found that Prrx1+ cell was essential for murine rotator
Han Xiao, Tao Zhang, Changjun Li, Yong Cao, Linfeng Wang, Huabin Chen, Shengcan Li, Changbiao Guan, Jianzhong Hu, Di Chen, Can Chen, Hongbin Lu   +11 more
doaj   +1 more source

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

eLife, 2015
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here, we investigated the molecular mechanisms by which mechanical force regulates Ca2+ signaling at endoplasmic reticulum (ER) in human mesenchymal stem cells. Without
Tae-Jin Kim, Chirlmin Joo, Jihye Seong, Reza Vafabakhsh, Elliot L Botvinick, Michael W Berns, Amy E Palmer, Ning Wang, Taekjip Ha, Eric Jakobsson, Jie Sun, Yingxiao Wang   +11 more
doaj   +1 more source

External physical and biochemical stimulation to enhance skeletal muscle bioengineering [PDF]

, 2015
Cell based muscle tissue engineering carries the potential to revert the functional loss of muscle tissue caused by disease and trauma. Although muscle tissue can be bioengineered using various precursor cells, major limitations still remain.; In the ...
Handschin, Christoph, Eberli, Daniel, Mortezavi, Ashkan, Plock, Jan, Plock, Jan; https://orcid.org/, Eberli, Daniel; https://orcid.org/   +5 more
core   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation [PDF]

, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Geisslinger, Gerd, Gerd Geisslinger, Brandes, Ralf P., Brandes, Ralf, Michael J Fischer, Fleming, Ingrid, Scholich, Klaus, Woolf Clifford J, Ralf P Brandes, Clifford J Woolf, Fleming Ingrid, Reeh, Peter Werner, Brenneis Christian, Fischer, Michael, Coste Ovidiu, Coste, Ovidiu, Brandes Ralf P, Kai Altenrath, Reeh Peter W, Christian Brenneis, Scholich Klaus, Sisignano, Marco, Reeh, Peter W., Altenrath Kai, Ingrid Fleming, Peter W Reeh, Woolf, Clifford J., Angioni Carlo, Geisslinger Gerd, Angioni, Carlo Federico, Klaus Scholich, Brenneis, Christian, Ovidiu Coste, Carlo Angioni, Sisignano Marco, Marco Sisignano, Fischer, Michael J., Fischer Michael J, Altenrath, Kai, Angioni, Carlo   +39 more
core   +3 more sources

Tension-compression loading with chemical stimulation results in additive increases to functional properties of anatomic meniscal constructs. [PDF]

PLoS ONE, 2011
This study aimed to improve the functional properties of anatomically-shaped meniscus constructs through simultaneous tension and compression mechanical stimulation in conjunction with chemical stimulation.Scaffoldless meniscal constructs were subjected ...
Daniel J Huey, Kyriacos A Athanasiou
doaj   +1 more source

Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential

, 2019
Cardiovascular diseases are the leading cause of death in developed countries. Consequently, the demand for effective cardiac cell therapies has motivated researchers in the stem cell and bioengineering fields to develop in vitro high-fidelity human ...
Bragós, Ramon, Bayés Genis, Antoni, Bayés-Genís, Antoni, Llucià-Valldeperas, Aida, Llucía Valldeperas, Aida, Bragós Bardia, Ramon   +5 more
core   +1 more source

Robotic trunk perturbation magnitude affects standing postural responses in individuals with motor complete spinal cord injury receiving epidural stimulation

Scientific Reports
After a severe spinal cord injury (SCI), the human spinal circuitry receiving epidural stimulation can generate lower limb postural responses to sensory inputs associated with trunk perturbation.
Enrico Rejc, Collin D. Bowersock, Tanvi Pisolkar, Simone Zaccaron, Claudia A. Angeli, Gail F. Forrest, Sunil Agrawal, Susan J. Harkema   +7 more
doaj   +1 more source

DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

JOR Spine, 2023
Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL.
Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu   +13 more
doaj   +1 more source