Results 101 to 110 of about 1,725,788 (328)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Pulmonary Endothelial Mechanical Sensing and Signaling, a Story of Focal Adhesions and Integrins in Ventilator Induced Lung Injury

Frontiers in Physiology, 2019
Patients with critical illness such as acute lung injury often undergo mechanical ventilation in the intensive care unit. Though lifesaving in many instances, mechanical ventilation often results in ventilator induced lung injury (VILI), characterized by
Gabriel T. Kelly, Reem Faraj, Yao Zhang, Emin Maltepe, Jeffrey R. Fineman, Stephen M. Black, Ting Wang   +6 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Challenges in CO₂ Conversion Using TiO₂-II Photocatalyst Synthesized by Mechanical Stress

, 2023
Saeid Akrami, Masayoshi Fuji
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Compression Stress Effect on Dislocations Movement and Crack propagation in Cubic Crystal [PDF]

, 2011
Fracture material is seriously problem in daily life, and it has connection with mechanical properties itself. The mechanical properties is belief depend on dislocation movement and crack propagation in the crystal.
Aprilia, Ely, Suprijadi, Yusfi, Meiqorry
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Plasticity of Expression of Stem Cell and EMT Markers in Breast Cancer Cells in 2D and 3D Culture Depend on the Spatial Parameters of Cell Growth; Mathematical Modeling of Mechanical Stress in Cell Culture in Relation to ECM Stiffness

Bioengineering
The majority of the current cancer research is based on two-dimensional cell cultures and animal models. These methods have limitations, including different expressions of key factors involved in carcinogenesis and metastasis, depending on culture ...
Małgorzata Szostakowska-Rodzoś, Mateusz Chmielarczyk, Weronika Zacharska, Anna Fabisiewicz, Agata Kurzyk, Izabella Myśliwy, Zofia Kozaryna, Eligiusz Postek, Ewa A. Grzybowska   +8 more
doaj   +1 more source

Relationship between fatigue life in the creep-fatigue region and stress-strain response [PDF]

On the basis of mechanical tests and metallographic studies, strainrange partitioned lives were predicted by introducing stress-strain materials parameters into the Universal Slopes Equation.
Berkovits, A., Nadiv, S.
core   +1 more source

The Constant-Stress, Constant-Heating-Rate Test: A Novel Method for Characterizing Transient Mechanical Behavior of Metallic Materials [PDF]

, 2021
S. L. Semiatin, P. N. Fagin, N. C. Levkulich, Brian T. Gockel, Bruce F. Antolovich, Ernie Crist, Jonathan Cormier, J. Tiley   +7 more
openalex   +1 more source