Results 111 to 120 of about 1,725,788 (328)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mechanical Stimulation of Red Blood Cells Aging: Focusing on the Microfluidics Application

Micromachines
Human red blood cells (RBCs) are highly differentiated cells, essential in almost all physiological processes. During their circulation in the bloodstream, RBCs are exposed to varying levels of shear stress ranging from 0.1–10 Pa under physiological ...
Alexander Gural, Ivana Pajić-Lijaković, Gregory Barshtein   +2 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Time-independent Anisotropic Plastic Behavior by Mechanical Subelement Models [PDF]

, 1983
The paper describes a procedure for modelling the anisotropic elastic-plastic behavior of metals in plane stress state by the mechanical sub-layer model.
Pian, T. H. H.
core   +1 more source

Review of: "PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells" [PDF]

, 2022
Madhu B. Anand‐Srivastava
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Resizing procedure for optimum design of structures under combined mechanical and thermal loading [PDF]

An algorithm is reported for resizing structures subjected to combined thermal and mechanical loading. The algorithm is applicable to uniaxial stress elements (rods) and membrane biaxial stress members.
Adelman, H. M., Narayanaswami, R.
core   +1 more source

Predicting early‐age stress evolution in restrained concrete by thermo‐chemo‐mechanical model and active ensemble learning [PDF]

, 2022
Minfei Liang, Ze Chang, Shan He, Yu Chen, Yidong Gan, Erik Schlangen, Branko Šavija   +6 more
openalex   +1 more source

Stress-induced Eukaryotic Translational Regulatory Mechanisms

ArXiv
The eukaryotic protein synthesis process entails intricate stages governed by diverse mechanisms to tightly regulate translation. Translational regulation during stress is pivotal for maintaining cellular homeostasis, ensuring the accurate expression of essential proteins crucial for survival.
Mir, Dilawar Ahmad, Ma, Zhengxin, Horrocks, Jordan, Rogers, Aric N   +3 more
openaire   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source