Results 241 to 250 of about 1,725,788 (328)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mechanical stress connects cortical folding to fiber organization in the developing brain. [PDF]

Trends Neurosci
Garcia KE, Kroenke CD, Bayly PV.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

PIEZO1-GPX4 Axis Mediates Mechanical Stress-Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation. [PDF]

Adv Sci (Weinh)
Chen F, Peng F, Chen S, Du Y, Li J, Fan Y, Cui Z, Gu G, Zhang H, Jiang Z, Wang G, Jing X, Dong J, Li T, Xi Y.   +14 more
europepmc   +1 more source

Assessing the Future ODYSEA Satellite Mission for the Estimation of Ocean Surface Currents, Wind Stress, Energy Fluxes, and the Mechanical Coupling between the Ocean and the Atmosphere

Marco Larrañaga, Lionel Renault, Alexander Wineteer, Marcela Contreras, Brian K. Arbic, Mark A. Bourassa, Ernesto Rodríguez   +6 more
openalex   +1 more source

Thermo-Mechanical Simulation Model Development on Residual Stresses in Rolled Aluminium Alloy

, 2018
Purnendu Mondal, C. Pinna
openalex   +1 more source

Mechanical sensing mechanisms: shear stress and endothelial cells

Journal of Vascular Surgery, 1991
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation. [PDF]

Adv Sci (Weinh)
Wang Z, Li Z, Wang L, Zhang H, Yang X, Bao L, Dou G, Ren L, Fu Y, Li L, Gong S, Zhou Y, Ding F, Yu L, Luo H, Liu Y, Zhang F, Yu H, Liu S, Liu X, Wei F, Liu S.   +21 more
europepmc   +1 more source

Modeling the mechanical properties of rock at different pore and confining pressures using the grain-based stress corrosion model

Teng-Fei Fu, Defu Zhu, Yatao Li
openalex   +1 more source