Results 161 to 170 of about 1,697,500 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Risk assessment for condylar stress fracture in elite racing Thoroughbreds using standing computed tomography-based virtual mechanical testing. [PDF]

Equine Vet J
Brown NL, Irandoust S, Thom EJ, Whitton RC, Henak CR, Muir P.   +5 more
europepmc   +1 more source

Mechanical testing data from neutron irradiations of PM-HIP and conventionally manufactured nuclear structural alloys. [PDF]

Data Brief, 2023
Wharry JP, Clement CD, Zhao Y, Baird K, Frazer D, Burns J, Lu Y, Wu Y, Knight C, Guillen DP, Gandy DW.   +10 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Geometric Parameter Optimization of 3D-Printed Microneedle Arrays Based on Comprehensive Mechanical Testing and Failure Analysis. [PDF]

Micromachines (Basel)
Aldawood FK, Abualkhair HF.
europepmc   +1 more source

Fabrication and Mechanical Testing of the Uniaxial Graded Auxetic Damper. [PDF]

Materials (Basel), 2022
Al-Rifaie H, Novak N, Vesenjak M, Ren Z, Sumelka W.   +4 more
europepmc   +1 more source

Thermoplastic coating of carbon fibers [PDF]

Using a continuous powder coating process, more than 1500 meters of T 300/LaRC-TPI prepreg were produced. Two different types of heating sections in the coating line, namely electrical resistance and convection heating, were utilized. These prepregs were
Edie, D. D., Lickfield, G. C.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Automated and manual model creation workflows are equally reliable for virtual mechanical testing of ovine bone and fracture healing. [PDF]

Sci Rep
Bahrami M, Ariyanfar A, Klein K, von Rechenberg B, Darwiche S, Dailey HL.   +5 more
europepmc   +1 more source

Microscale and Macroscale Deformation Behavior of Electrospun Polymeric Nanofiber Membranes Using In Situ SEM during Mechanical Testing. [PDF]

Polymers (Basel), 2023
Verschatse O, Loccufier E, Swanckaert B, De Clerck K, Daelemans L.   +4 more
europepmc   +1 more source