Results 171 to 180 of about 1,697,500 (308)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Experimental datasets from mechanical testing and characterization of composites filled with PVCs waste. [PDF]

Data Brief
Nugraha AD, Purnomo E, Afandi FR, Wijayanto H, Yudha NK, Supriyanto E, Nugroho AD, Muflikhun MA.   +7 more
europepmc   +1 more source

A Bayesian constitutive model selection framework for biaxial mechanical testing of planar soft tissues: Application to porcine aortic valves. [PDF]

J Mech Behav Biomed Mater, 2023
Aggarwal A, Hudson LT, Laurence DW, Lee CH, Pant S.   +4 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Density-Based Topology-Optimized 3D-Printed Fixtures for Cyclic Mechanical Testing of Lattice Structures. [PDF]

Polymers (Basel)
Castro J, Valle R, Leiva J, Oñate A, Saggionetto E, Mertens A, Tuninetti V.   +6 more
europepmc   +1 more source

Vibrometry as a noncontact alternative to dynamic and viscoelastic mechanical testing in cartilage. [PDF]

J R Soc Interface, 2021
Espinosa MG, Otarola GA, Hu JC, Athanasiou KA.   +3 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Comprehensive Mechanical Testing of Polyacrylamide Hydrogels: The Impact of Crosslink Density. [PDF]

Polymers (Basel)
Antipova CG, Krupnin AE, Zakirov AR, Pobezhimov VV, Romanenko DA, Stolyarova DY, Chvalun SN, Grigoriev TE.   +7 more
europepmc   +1 more source

Mechanical testing of transtibial prosthetic sockets: A discussion paper from the American Orthotic and Prosthetic Association Socket Guidance Workgroup. [PDF]

Prosthet Orthot Int, 2023
Gariboldi F, Cutti AG, Fatone S, Nickel E, Dickinson A, Steer J, Erenstone J, Zahedi S, AOPA Socket Guidance Workgroup.   +8 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source