Results 181 to 190 of about 1,690,858 (288)

Fabricating a Low-Cost, Microscopy-Compatible Mechanical Testing Device. [PDF]

Exp Tech, 2022
Mehta SM, De Santos DR, Sridhar S, Aguayo VC, Meraz CA, Mikos M, Grande-Allen KJ.   +6 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Surface and Subsurface Mechanical Testing at the Nanoscale: A Review on Ultrasonic Atomic Force Microscopy. [PDF]

Langmuir
Ma C, Zhou F.
europepmc   +1 more source

Robot and mechanical testing of a specialist manual toothbrush for cleaning efficacy and improved force control. [PDF]

BMC Oral Health, 2022
Acherkouk A, Götze M, Kiesow A, Ramakrishnan A, Sarembe S, Lang T, Gaengler P.   +6 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Mitigation of image distortion during mechanical testing within a dynamic stereo x-ray system. [PDF]

Front Bioeng Biotechnol
Paglia DN, Chomack JM, Herlihy DV, Wetterstrand C, Kadkoy Y, Duchnycz R, Kelly P, O'Connor JP, D'Andrea SE, Maikos JT.   +9 more
europepmc   +1 more source

Mechanical testing of frontal plane adaptability of commercially available prosthetic feet. [PDF]

J Rehabil Assist Technol Eng, 2022
Wernke MM, Ficanha EM, Thomas Z, Maitland ME, Allyn KJ, Albury A, Colvin J.   +6 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Rings in Taylor Spatial Frame: Mechanical testing and finite element analysis. [PDF]

Proc Inst Mech Eng H
Zamani A, Zenios M, Oyadiji SO.
europepmc   +1 more source

Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones. [PDF]

Sci Rep, 2022
Inglis B, Schwarzenberg P, Klein K, von Rechenberg B, Darwiche S, Dailey HL.   +5 more
europepmc   +1 more source