Results 71 to 80 of about 832,948 (254)
General Multi-Fidelity Framework for Training Artificial Neural Networks With Computational Models
Frontiers in Materials, 2019 Training of artificial neural networks (ANNs) relies on the availability of training data. If ANNs have to be trained to predict or control the behavior of complex physical systems, often not enough real-word training data are available, for example ...
Roland Can Aydin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Damage Modelling of Compressed Earth Blocks Stabilised with Cement
Advances in Civil Engineering, 2022 This work aims at studying the mechanical behaviour of compressed Earth blocks (CEBs) and compressed stabilised Earth blocks (CSEBs) with 4% and 8% in weight cement stabilisation.
Janvier Goutsaya +2 more
doaj +1 more source
Onsager’s variational principle in soft matter : introduction and application to the dynamics of adsorption of proteins onto fluid membranes [PDF]
, 2018 This book is the first collection of lipid-membrane research conducted by leading mechanicians and experts in continuum mechanics. It brings the overall intellectual framework afforded by modern continuum mechanics to bear on a host of challenging ...
Arroyo Balaguer, Marino +3 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Mechanics of materials model [PDF]
The Mechanics of Materials Model (MOMM) is a three-dimensional inelastic structural analysis code for use as an early design stage tool for hot section components.
Meister, Jeffrey P.
core +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Development of a High Strength Mg-9Li Alloy via Multi-Pass ECAP and Post-Rolling
Metals, 2019 In this study, a high-strength Mg-9Li alloy was developed via multi-pass equal-channel-angular-pressing (ECAP) and post rolling, of which the yield tensile stress (YTS) and ultimate tensile stress (UTS) were 166 MPa and 174 MPa representing about 219 ...
Edwin Eyram Klu +8 more
doaj +1 more source