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Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals

open access: yeseLife, 2023
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations.
Zhipeng Wang   +19 more
doaj   +1 more source

Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer

open access: yesCancer Nanotechnology, 2023
Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen   +10 more
doaj   +1 more source

SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns

open access: yesNature Communications, 2021
The length distribution of human pre-mRNA introns is very extensive. The authors demonstrate that splicing in a subset of short introns is dependent on SPF45 (RBM17), which replaces authentic U2AF-heterodimer on the truncated poly-pyrimidine tracts and ...
Kazuhiro Fukumura   +7 more
doaj   +1 more source

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

open access: yesCell & Bioscience, 2021
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant ...
Ayslan Castro Brant   +4 more
doaj   +1 more source

αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell-cycle progression

open access: yesCell Reports, 2023
Summary: Increased metabolic activity usually provides energy and nutrients for biomass synthesis and is indispensable for the progression of the cell cycle.
Yanting Yang   +5 more
doaj   +1 more source

Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

open access: yesAMB Express, 2021
Bacterial biofilms formation is one of the major reasons for treatment failure in chronic wound infections. Therefore, diagnostic biomarkers remain the best option for prevention and treatment of chronic wound infections by biofilms.
Xiaojuan Tan   +6 more
doaj   +1 more source

In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

open access: yesGenome Biology, 2023
Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation.
Junbo Liang   +11 more
doaj   +1 more source

Proteomic and functional profiling of platelet-derived extracellular vesicles released under physiological or tumor-associated conditions

open access: yesCell Death Discovery, 2022
During hemostasis, thrombosis, and inflammation, activated blood platelets release extracellular vesicles (PEVs) that represent biological mediators of physiological and pathological processes.
Mauro Vismara   +8 more
doaj   +1 more source

Studies on the cold tolerance of ratoon ‘Chaling’ common wild rice

open access: yesBiological Research, 2020
Background Rice is the staple food of many people around the world. However, most rice varieties, especially widely grown indica varieties and hybrids, are sensitive to cold stress.
Mengliang Xu   +5 more
doaj   +1 more source

Alkaline phosphatase LapA regulates quorum sensing–mediated virulence and biofilm formation in Pseudomonas aeruginosa PAO1 under phosphate depletion stress

open access: yesMicrobiology Spectrum, 2023
Among various environmental stresses, the depletion of inorganic phosphate, which is an important signaling molecule that modulates virulence production, is notable. In our previous study, we demonstrated that lapA, encoding alkaline phosphatase, plays a
Xiaojuan Tan   +8 more
doaj   +1 more source

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