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The concept of mechanism in biology. [PDF]

open access: yesStudies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 2012
The concept of mechanism in biology has three distinct meanings. It may refer to a philosophical thesis about the nature of life and biology (‘mechanicism’), to the internal workings of a machine-like structure (‘machine mechanism’), or to the causal ...
D. Nicholson
semanticscholar   +6 more sources

Mathematics at the eve of a historic transition in biology [PDF]

open access: yesarXiv, 2017
A century ago physicists and mathematicians worked in tandem and established quantum mechanism. Indeed, algebras, partial differential equations, group theory, and functional analysis underpin the foundation of quantum mechanism. Currently, biology is undergoing a historic transition from qualitative, phenomenological and descriptive to quantitative ...
Wei, Guo-Wei
arxiv   +4 more sources

RNA Interference: Biology, Mechanism, and Applications [PDF]

open access: greenMicrobiology and Molecular Biology Reviews, 2003
SUMMARY Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression in a range of organisms. The silencing of a gene is a consequence of degradation of RNA into short RNAs that activate ribonucleases to ...
Neema Agrawal   +5 more
openalex   +2 more sources

Homeostasis as the Mechanism of Evolution [PDF]

open access: yesBiology, 2015
Homeostasis is conventionally thought of merely as a synchronic (same time) servo-mechanism that maintains the status quo for organismal physiology. However, when seen from the perspective of developmental physiology, homeostasis is a robust, dynamic ...
J. Torday
semanticscholar   +4 more sources

Target identification and mechanism of action in chemical biology and drug discovery [PDF]

open access: greenNature Chemical Biology, 2013
Monica Schenone   +3 more
openalex   +2 more sources

Magnetic field effects in biology from the perspective of the radical pair mechanism [PDF]

open access: yesJournal of the Royal Society Interface, 2022
Hundreds of studies have found that weak magnetic fields can significantly influence various biological systems. However, the underlying mechanisms behind these phenomena remain elusive.
Hadi Zadeh-Haghighi, C. Simon
semanticscholar   +1 more source

Identification of quiescent FOXC2+ spermatogonial stem cells in adult mammals

open access: yeseLife, 2023
In adult mammals, spermatogenesis embodies the complex developmental process from spermatogonial stem cells (SSCs) to spermatozoa. At the top of this developmental hierarchy lie a series of SSC subpopulations.
Zhipeng Wang   +19 more
doaj   +1 more source

Generation of magnetic biohybrid microrobots based on MSC.sTRAIL for targeted stem cell delivery and treatment of cancer

open access: yesCancer Nanotechnology, 2023
Background Combining the power of magnetic guidance and the biological activities of stem cells transformed into biohybrid microrobots holds great promise for the treatment of several diseases including cancer.
Rebekah Anamarie Gundersen   +10 more
doaj   +1 more source

SPF45/RBM17-dependent, but not U2AF-dependent, splicing in a distinct subset of human short introns

open access: yesNature Communications, 2021
The length distribution of human pre-mRNA introns is very extensive. The authors demonstrate that splicing in a subset of short introns is dependent on SPF45 (RBM17), which replaces authentic U2AF-heterodimer on the truncated poly-pyrimidine tracts and ...
Kazuhiro Fukumura   +7 more
doaj   +1 more source

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