Results 31 to 40 of about 12,217,563 (347)
Molecular mechanisms of telomere biology disorders [PDF]
Journal of Biological Chemistry, 2021 Genetic mutations that affect telomerase function or telomere maintenance result in a variety of diseases collectively called telomeropathies. This wide spectrum of disorders, which include dyskeratosis congenita, pulmonary fibrosis, and aplastic anemia, is characterized by severely short telomeres, often resulting in hematopoietic stem cell failure in
Sherilyn Grill, Jayakrishnan Nandakumar
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Collective oscillation period of inter-coupled biological negative cyclic feedback oscillators [PDF]
, 2014 A number of biological rhythms originate from networks comprised of multiple cellular oscillators. But analytical results are still lacking on the collective oscillation period of inter-coupled gene regulatory oscillators, which, as has been reported ...
Doyle III, Francis J. +3 more
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Untangling the Conceptual Isssues Raised in Reydon and Scholz’s Critique of Organizational Ecology and Darwinian Populations [PDF]
, 2014 Reydon and Scholz raise doubts about the Darwinian status of organizational ecology by arguing that Darwinian principles are not applicable to organizational populations.
Aldrich H. E. +31 more
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MicroRNAs: From Mechanism to Organism
Frontiers in Cell and Developmental Biology, 2020 MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts. The emergence of small RNA-mediated gene silencing preceded the onset of multicellularity and was followed by a ...
Philip Dexheimer, L. Cochella
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Highly Optimized Tolerance: Robustness and Power Laws in Complex Systems [PDF]
, 1998 We introduce highly optimized tolerance (HOT), a mechanism that connects evolving structure and power laws in interconnected systems. HOT systems arise, e.g., in biology and engineering, where design and evolution create complex systems sharing common ...
Carlson, J. M., Doyle, John
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Biophysical Journal, 1962 I should like to begin by saying that I feel very diffident about speaking on the subject which the organizers of this Conference invited me to discuss with you. What I have to say will inevitably be limited by the extreme superficiality of my acquaintance with modem biochemistry and biophysics.
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Buckling of a growing tissue and the emergence of two-dimensional patterns [PDF]
, 2013 The process of biological growth and the associated generation of residual stress has previously been considered as a driving mechanism for tissue buckling and pattern selection in numerous areas of biology.
Jensen, OE, King, JR, Nelson, MR
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Color Atlas of Clinical Hematology, 1990 Much of the research in the Pringle laboratory exploits the power of yeast as an experimentally tractable model eukaryote to investigate fundamental problems in cell and developmental biology such as the mechanisms of cell polarization and cytokinesis ...
S. Dolomatov, E. Ageeva, Walery Zukow
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NF-κB in biology and targeted therapy: new insights and translational implications
Signal Transduction and Targeted TherapyNF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo +8 more
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Alternative activation of macrophages: mechanism and functions.
Immunity, 2010 The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease.
S. Gordon, F. Martínez
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