Results 31 to 40 of about 2,474,961 (353)
CRISPR-Cas: biology, mechanisms and relevance [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2016 Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) display a prokaryotic adaptive immune system that memorizes previous infections by integrating short sequences of invading genomes—termed spacers—into the ...
Frank Hille, Emmanuelle Charpentier
openaire +4 more sources
Genetically encoded fluorescent redox probes. [PDF]
, 2013 Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling.
Ai, Hui-Wang, Ren, Wei
core +3 more sources
Identification of the effect of cisplatin on the transcriptome of human hepatocellular carcinoma cell lines [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of cisplatin treatment on the transcriptional level of human liver cancer cells by conducting transcriptome sequencing analysis after treating human liver cancer cell lines with different concentrations of cisplatin ...
GUO Xin, JI Mengdie, WANG Qi, LI Xueyuan, CHEN Yang
doaj +1 more source
Biophysical Journal, 1962 I should like to begin by saying that I feel very diffident about speaking on the subject which the organizers of this Conference invited me to discuss with you. What I have to say will inevitably be limited by the extreme superficiality of my acquaintance with modem biochemistry and biophysics.
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Cell Reports, 2023 Summary: Increased metabolic activity usually provides energy and nutrients for biomass synthesis and is indispensable for the progression of the cell cycle.
Yanting Yang +5 more
doaj
Highly Optimized Tolerance: Robustness and Power Laws in Complex Systems [PDF]
, 1998 We introduce highly optimized tolerance (HOT), a mechanism that connects evolving structure and power laws in interconnected systems. HOT systems arise, e.g., in biology and engineering, where design and evolution create complex systems sharing common ...
Carlson, J. M., Doyle, John
core +2 more sources
Network topology drives population temporal variability in experimental habitat networks
Population Ecology, EarlyView.Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu +3 more
wiley +1 more source
Untangling the Conceptual Isssues Raised in Reydon and Scholz’s Critique of Organizational Ecology and Darwinian Populations [PDF]
, 2014 Reydon and Scholz raise doubts about the Darwinian status of organizational ecology by arguing that Darwinian principles are not applicable to organizational populations.
Aldrich H. E. +31 more
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Caloric restriction, Sirtuins, and cardiovascular diseases
Chinese Medical Journal. Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD+
Ziyu Wei +7 more
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