Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Pseudogene GTF3AP2 is involved in the regulation of erythroid differentiation [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of pseudogene GTF3AP2 in erythroid differentiation. Methods The published high-throughput RNA sequencing(RNA-seq) data were analyzed to identify the functional pseudogene GTF3AP2, which may play a role in ...
XIA Lan, RONG Yu, XIA Hongkai, MA Yanni, YU Jia
doaj +1 more source
Quantitative proteomics and lipidomics of TFG-deficient B cells provide insights into mechanisms of autophagic flux and plasma cell biology [PDF]
, 2022 Tobit Steinmetz +10 more
openalex +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Effect of ergothioneine on tissue metabolism in middle-aged and aged mice [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of ergothioneine(EGT) on tissue metabolism in middle-aged and aged mice. Methods Nine-month-old middle-aged and aged C57BL/6J mice were selected to be gavaged with EGT aqueous solution at the dose and frequency of 35 ...
CHEN Haoran, WANG Fang, MA Yanni, YU Jia, WANG Lin
doaj +1 more source
Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways [PDF]
, 2020 Monica Kam Draskau +4 more
openalex +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
PWP1 is overexpressed in hepatocellular carcinoma and facilitates liver cancer cell proliferation
HeliyonIdentification of novel biomarkers for prediction of disease course and prognosis is needed to reduce morbidity of liver hepatocellular carcinoma (LIHC/HCC) patients.
Rong Huang +8 more
doaj +1 more source
Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology [PDF]
, 2020 Zi Yang +5 more
openalex +1 more source