Results 61 to 70 of about 12,217,563 (347)
BMC Infectious DiseasesInfluenza-related acute lung injury is a life-threatening condition primarily caused by uncontrolled replication of the influenza virus and intense proinflammatory responses.
Lifang Zhang +7 more
doaj +1 more source
Molecular Architecture and Biological Reactions [PDF]
, 1946 Answers to many basic problems of biology—nature of growth, mechanism of duplication of viruses and genes , action of enzymes, mechanism, of physiological activity of drugs, hormones, and vitamins, structure and action of nerve and brain tissue—may ...
Pauling, Linus
core
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Identification of homologous protein models via 3D comparisons using predicted structures
STAR ProtocolsSummary: Recent advances in protein structure prediction enable 3D homology alignment and domain annotation using tertiary structures. Here, we present a protocol to identify homologous structures and annotate protein domains through in silico ...
Anyu Pan +4 more
doaj +1 more source
Identification of the effect of cisplatin on the transcriptome of human hepatocellular carcinoma cell lines [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of cisplatin treatment on the transcriptional level of human liver cancer cells by conducting transcriptome sequencing analysis after treating human liver cancer cell lines with different concentrations of cisplatin ...
GUO Xin, JI Mengdie, WANG Qi, LI Xueyuan, CHEN Yang
doaj +1 more source
Inter-Tunneling Mechanism of Colliding Population Waves [PDF]
, 2012 Here we show a new interaction mechanism of colliding population waves. It provides a stable coexistence of two similar but different species competing for the same limiting resource during their asexual propagation in a limited homogeneous environment ...
Lev V. Kalmykov, Vyacheslav L. Kalmykov
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
VirusesInfluenza A virus (IAV) remains a major global health threat, and host-directed antivirals may help overcome rapid viral mutation and drug resistance.
Qingchao Zhang +7 more
doaj +1 more source
The future of biosensors [PDF]
, 1996 Since the development of the glucose sensor by Clark and Lyons in 1962, generally recognized as the first biosensor, many types of sensors have been developed in which a physical or chemical transducer is provided with a layer containing a biological ...
Bergveld, P.
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source