Results 61 to 70 of about 2,572,200 (301)

Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, 2021
The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic pathways, including redox homeostasis, iron handling, mitochondrial activity and metabolism of amino
Xuejun Jiang, Brent R. Stockwell, Marcus Conrad   +2 more
openaire   +4 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

An Ultra‐Fast Rolling Double‐Helical Robot Driven by Constant Humidity

Advanced Science
Untethered soft robots made of stimuli‐responsive materials hold great application potential in various fields. However, most robots of this type require artificial modulation of the stimuli to actuate, while it is a great challenge to achieve fast ...
Chuhan Xu, Jiayao Ma, Lei Fu, Xinmeng Liu, Lei Zhang, Yan Chen   +5 more
doaj   +1 more source

Apparent competition drives community-wide parasitism rates and changes in host abundance across ecosystem boundaries [PDF]

, 2016
Species have strong indirect effects on others, and predicting these effects is a central challenge in ecology. Prey species sharing an enemy (predator or parasitoid) can be linked by apparent competition, but it is unknown whether this process is strong
Didham, RK, Frost, CM, Peralta, G, Rand, TA, Tylianakis, JM, Varsani, A   +5 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Application of different methods used to transfect small molecule NADPH into cells [PDF]

Jichu yixue yu linchuang
Objective To compare the three different methods for direct transfection of small exogenous nicotinamide adenine dinucleotide phosphate(NADPH) into cells by a non-metabolic pathway.
LI Haoyue, DU Wenjing, LI Wei
doaj   +1 more source

Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy [PDF]

, 2017
Hypertension during pregnancy is the most common medical condition encountered during gestation. Despite this, knowledge of the mechanisms that underlie the disease and the development of new therapies are limited.
Cornelius, Denise C., Delles, Christian, Guzik, Tomasz J., Small, Heather Yvonne   +3 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Universal Mortality Law, Life Expectancy and Immortality

, 2004
Well protected human and laboratory animal populations with abundant resources are evolutionary unprecedented, and their survival far beyond reproductive age may be a byproduct rather than tool of evolution.
Arantes-Oliveira, Azbel', Azbel', Azbel', Carey, Carnes, Charlesworth, Coale, Curtsinger, Deevey, Euler, Finch, Gompertz, Halley, Jazwinsi, Kirkwood, Mair, Mark Ya. Azbel', Olshansky, Pearl, Shama, Stauffer, Strehler, Vaupel, Yu   +24 more
core   +1 more source

On robust stability of stochastic genetic regulatory networks with time delays: A delay fractioning approach [PDF]

, 2010
Copyright [2009] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services.
Liang, J, Wang, Y, Wang, Z
core   +1 more source