Results 71 to 80 of about 2,572,200 (301)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Integrative analysis of single-cell and bulk transcriptome data reveals age-related immune cell alterations in primary glioblastoma associated with prognosis

Cancer Immunology, Immunotherapy
Background Glioblastoma (GBM) is the most malignant and highly recurrent brain tumor. Although over half of the GBM patients are elderly patients, the understanding of how aging affects GBM progression remains limited.
Zefan Jing, Bojun Qiu, Chenyang Ai, Chunhui Wang, Xinrun Wang, Boyang Li, Lin Hou, Bin Yin, Wei Han, Xiaozhong Peng   +9 more
doaj   +1 more source

Kinetic Model of Translational Autoregulation

, 2018
We investigate dynamics of a kinetic model of inhibitory autoregulation as exemplified when a protein inhibits its own production by interfering with its messenger RNA, known in molecular biology as translational autoregulation.
Kellman, Michael E., Tyng, Vivian
core   +2 more sources

Backbone chemical shift assignments of human 14-3-3$\sigma$ [PDF]

, 2019
14-3-3 proteins are a group of seven dimeric adapter proteins that exert their biological function by interacting with hundreds of phosphorylated proteins, thus influencing their sub-cellular localization, activity or stability in the cell.
Boll, Emmanuelle, Cantrelle, François-Xavier, Hanoulle, Xavier, Landrieu, Isabelle, Merzougui, Hamida, Neves, João   +5 more
core   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Enhanced B cell electroporation efficiency via inhibition of DNA-induced apoptosis and pyroptosis with pan-caspase inhibitor

Molecular Therapy: Methods & Clinical Development
B cells have immense potential as gene therapy carriers because of their ability to secrete therapeutic proteins and mediate immunological memory and tolerogenic functions. However, efficient gene delivery into primary B cells remains a challenge, as DNA
Gui-Lin Yang, Deng-Gao Wang, Xiang Zhao, De-Long Hao, Zhu-Qin Zhang, De-Pei Liu   +5 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Pseudogene GTF3AP2 is involved in the regulation of erythroid differentiation [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of pseudogene GTF3AP2 in erythroid differentiation. Methods The published high-throughput RNA sequencing(RNA-seq) data were analyzed to identify the functional pseudogene GTF3AP2, which may play a role in ...
XIA Lan, RONG Yu, XIA Hongkai, MA Yanni, YU Jia
doaj   +1 more source

Universal scaling relation in high-temperature superconductors

, 2004
Scaling laws express a systematic and universal simplicity among complex systems in nature. For example, such laws are of enormous significance in biology. Scaling relations are also important in the physical sciences.
A Pimenov, AV Pronin, AV Puchkov, C Niedermayer, C. C. Homes, CC Homes, CC Homes, CC Homes, D. A. Bonn, D. N. Basov, DB Tanner, DN Basov, DN Basov, DN Basov, EJ Singley, G. Yu, H Eisaki, HL Liu, J Orenstein, J Schützmann, JG Bednorz, LN Bulaevskii, M. Greven, M. Strongin, N. Kaneko, O Klein, Ruixing Liang, S Chakravarty, S. V. Dordevic, Seiki Komiya, SV Dordevic, T Shibauchi, T Startseva, T. Timusk, V Ambegaokar, W. N. Hardy, WE Lawrence, WN Hardy, X. Zhao, Y Ando, YJ Uemura, Yoichi Ando, Z-X Shen   +42 more
core   +1 more source

Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]

, 2012
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature.
Cellière, Géraldine, Iber, Dagmar, Menshykau, Denis   +2 more
core   +3 more sources