Results 71 to 80 of about 10,501,738 (419)
A. Sergi, Atti della Accademia Peloritana dei Pericolanti Vol.
LXXXVII, C1C0901001 (2009), 2009 A critical assessment of the recent developments of molecular biology is presented. The thesis that they do not lead to a conceptual understanding of life and biological systems is defended. Maturana and Varela's concept of autopoiesis is briefly sketched and its logical circularity avoided by postulating the existence of underlying {\it living ...
arxiv +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The challenges of purely mechanistic models in biology and the minimum need for a 'mechanism-plus-X' framework [PDF]
, 2018 Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences,
Ehsani, Sepehr
core +1 more source
A Null-model Exhibiting Synchronized Dynamics in Uncoupled Oscillators
, 2018 The phenomenon of phase synchronization of oscillatory systems arising out of feedback coupling is ubiquitous across physics and biology. In noisy, complex systems, one generally observes transient epochs of synchronization followed by non-synchronous ...
Chakrabortty, Tuhin +4 more
core +1 more source
Adaptation using hybridized genetic crossover strategies [PDF]
Physica A 322, 701 (2003), 2002 We present a simple game which mimics the complex dynamics found in most natural and social systems. Intelligent players modify their strategies periodically, depending on their performances. We propose that the agents use hybridized one-point genetic crossover mechanism,inspired by genetic evolution in biology, to modify the strategies and replace the
arxiv +1 more source
Causal Concepts in Biology: How Pathways Differ from Mechanisms and Why It Matters
British Journal for the Philosophy of Science, 2020 Over the last two decades few topics in philosophy of science have received as much attention as mechanistic explanation. A significant motivation for these accounts is that scientists frequently use the term ‘mechanism’ in their explanations of ...
Lauren N. Ross
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
BMC Infectious DiseasesInfluenza-related acute lung injury is a life-threatening condition primarily caused by uncontrolled replication of the influenza virus and intense proinflammatory responses.
Lifang Zhang +7 more
doaj +1 more source
Vibrations, Quanta and Biology [PDF]
Contemp. Phys. 54, 181 - 207 (2013), 2013 Quantum biology is an emerging field of research that concerns itself with the experimental and theoretical exploration of non-trivial quantum phenomena in biological systems. In this tutorial overview we aim to bring out fundamental assumptions and questions in the field, identify basic design principles and develop a key underlying theme -- the ...
arxiv +1 more source
Chemically induced proximity in biology and medicine
Science, 2018 Regulating molecule proximity The physical distance, or proximity, between molecules often directs biological events. The development of membrane-permeable small molecules that reversibly regulate proximity has enabled advances in fields such as ...
Benjamin Z. Stanton +2 more
semanticscholar +1 more source