Results 81 to 90 of about 10,501,738 (419)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
, 2001 We review the recent fast progress in statistical physics of evolving networks. Interest has focused mainly on the structural properties of random complex networks in communications, biology, social sciences and economics.
Carlos Riveros +3 more
core +3 more sources
FEBS Letters, EarlyView.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Effects of intraperitoneal injection of busulfan on metabolic characteristics of spermatogonial stem cells [PDF]
Jichu yixue yu linchuangObjective To establish a mouse model treated with busulfan and to investigate its effects on the metabolism of spermatogonial stem cells (SSCs) of mouse testis.
YU Zhixin, MANG Xinyu, ZOU Dingfeng, MIAO Shiying, SONG Wei, LI Kai
doaj +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Active motions of Brownian particles in a generalized energy-depot model
, 2008 We present a generalized energy-depot model in which the conversion rate of the internal energy into motion can be dependent on the position and the velocity of a particle.
Chul Koo Kim +9 more
core +1 more source
Epithelial-mesenchymal interactions: a fundamental Developmental Biology mechanism.
International Journal of Developmental Biology, 2014 Interactions between epithelium and mesenchyme are common features of early stages of morphogenesis in different organs. In this historical review article, we retrospectively analyze the most important contribution to the definition and characterization ...
D. Ribatti, M. Santoiemma
semanticscholar +1 more source
Regulatory Mechanisms in Stem Cell Biology [PDF]
Cell, 1997 Stem cells are a subject of intense and increasing interest because of their biological properties and potential medical importance. Unfortunately, the field has been difficult for the nonspecialist to penetrate, in part because of ambiguity about what exactly constitutes a stem cell.
Morrison, Sean J. +2 more
openaire +4 more sources
FEBS Letters, EarlyView.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
Heat-induced denaturation of cataract-related human γD-crystallin [PDF]
Jichu yixue yu linchuangObjective To reveal the thermally induced denaturation of wild-type human γD-crystallin(HGD) and congenital cataract-related mutant (HGD P23T), and compare the differences in the structural changes between wild-type and mutants during a heating process.
ZHOU Xin, LI Zhenyan, LI Shuyuan, ZHANG Wenbo, WANG Chenxuan
doaj +1 more source