Results 181 to 190 of about 997,241 (253)

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies. [PDF]

Front Pharmacol
Li Z, Wang X, Shi Q, Guo Y, Dong G, Liu Z.   +5 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The "ADC-after-ADC" paradigm: navigating cross-resistance and sequencing in breast cancer therapy. [PDF]

Front Oncol
Asare M, Okobi TO, Karass S, Okobi JT, Taiwo E.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Ensemble learning-based online sequential pre-interference extreme learning for concept drifting and class imbalanced data streams. [PDF]

PLoS One
Huang Y, Wen H, Tang Q, Liu H.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

ACO-Enhanced DCNN-BiLSTM framework for intrusion detection in smart Consumer Electronics network. [PDF]

PLoS One
Chandroth J, Stoian G, Hemanth DJ.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Revisional surgery for delayed gastric conduit emptying after esophagectomy: the RESTORANT project. [PDF]

Dis Esophagus
Schneider MA, Davies A, O'Brien C, Baker C, Gossage J, Elliott J, Raftery N, Ahmed R, Klevebro F, Nilsson M, Norén N, Meier Adamenko O, Griffiths E, Butterworth W, Schlößer H, Bruns C, Tzitzili E, Nickel F, Kemper M, Zgurskyi P, Luyer M, Geraedts T, Bonavina L, Aiolfi A, Gockel I, Thieme R, Niebisch S, Kraljevic M, Müller B, Cron L, Berlth F, Milazzo A, Sgromo B, Harris H, Moletta L, Valmasoni M, Hubka M, Giacopuzzi S, Collizzolli A, Rosati R, Carresi A, Battaglia S, Santi S, Gualtierotti M, Rebecchi F, d'Avalos LV, Pera M, Biel E, Hölscher A, Hemmerich M, Cheong E, Van Daele E, Vanommeslaeghe H, Nezi G, Klarenbeek B, Grimminger P, Gutschow CA, For The Restorant Working Group.   +57 more
europepmc   +1 more source

Mamba-based state-space modeling with window attention for explainable multi-class gastrointestinal disease diagnosis in endoscopic images. [PDF]

Front Artif Intell
Tanwar V, Sharma B, Webber JL, Mehbodniya A.   +3 more
europepmc   +1 more source