Results 11 to 20 of about 997,241 (253)

Common activation mechanism of class A GPCRs

eLife, 2019
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third of all marketed drugs target members of ...
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao   +15 more
doaj   +3 more sources

Computability classes for enforcement mechanisms [PDF]

ACM Transactions on Programming Languages and Systems, 2006
A precise characterization of those security policies enforceable by program rewriting is given. This also exposes and rectifies problems in prior work, yielding a better characterization of those security policies enforceable by execution monitors as well as a taxonomy of enforceable security policies.
Kevin W. Hamlen, J. Gregory Morrisett, Fred B. Schneider   +2 more
openaire   +2 more sources

Structural-Parametric Synthesis of the RoboMech Class Parallel Mechanism with Two Sliders

Applied Sciences, 2021
This paper addresses the structural-parametric synthesis and kinematic analysis of the RoboMech class of parallel mechanisms (PM) having two sliders.
Zhumadil Baigunchekov, Med Amine Laribi, Giuseppe Carbone, Azamat Mustafa, Bekzat Amanov, Yernar Zholdassov   +5 more
doaj   +1 more source

Molecular-level nucleation mechanism of iodic acid and methanesulfonic acid [PDF]

Atmospheric Chemistry and Physics, 2022
Both iodic acid (HIO3, IA) and methanesulfonic acid (CH3S(O)2OH, MSA) have been identified by field studies as important precursors of new particle formation (NPF) in marine areas.
A. Ning, L. Liu, L. Ji, X. Zhang
doaj   +1 more source

Nanolattices: An Emerging Class of Mechanical Metamaterials

Advanced Materials, 2017
AbstractIn 1903, Alexander Graham Bell developed a design principle to generate lightweight, mechanically robust lattice structures based on triangular cells; this has since found broad application in lightweight design. Over one hundred years later, the same principle is being used in the fabrication of nanolattice materials, namely lattice structures
Bauer, Jens, Meza, Lucas R., Schaedler, Tobias A., Schwaiger, Ruth, Zheng, Xiaoyu, Valdevit, Lorenzo   +5 more
openaire   +4 more sources

Activation and Speciation Mechanisms in Class A GPCRs

Journal of Molecular Biology, 2022
Accurate development of allosteric modulators of GPCRs require a thorough assessment of their sequence, structure, and dynamics, toward gaining insights into their mechanisms of actions shared by family members, as well as dynamic features that distinguish subfamilies.
Wingert, Bentley, Doruker, Pemra, Bahar, Ivet   +2 more
openaire   +2 more sources

Refining the classification of knowledge transfer mechanisms for project-to-project knowledge sharing

South African Journal of Economic and Management Sciences, 2017
Background: The complex, unique and temporary nature of projects makes project-to-project knowledge transfer challenging and has attracted attention from both practitioners and academic scholars.
Corro Van Waveren, Leon Oerlemans, Tinus Pretorius   +2 more
doaj   +1 more source

RESEARCH CONCERNING THE POSITIONAL ANALYSIS OF A FOURTH CLASS MECHANISM [PDF]

Romanian Journal of Petroleum & Gas Technology
It is well known that with the increase in the class of mechanisms, the complexity of their analysis methods also increases accordingly. This is especially the case for mechanisms of class greater than four that contain kinematic groups whose structure ...
Georgeta Toma
doaj   +1 more source

Off-task social media multitasking during class: determining factors and mediating mechanism

International Journal of Educational Technology in Higher Education, 2022
Framed by social learning theory, the study examines a set of personal and social factors determining off-task social media multitasking inside university classrooms. We aim to clarify the relationships between social media multitasking and self-efficacy,
Liping Deng, Yujie Zhou, Qingchun Hu
doaj   +1 more source

Mechanism and Regulation of Class Switch Recombination [PDF]

Annual Review of Immunology, 2008
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a unique type of intrachromosomal deletional recombination within special G-rich tandem repeated DNA sequences [called switch, or S, regions located upstream of each of the heavy chain constant (CH) region genes, except Cδ].
Stavnezer, Janet, Guikema, Jeroen E. J., Schrader, Carol E.   +2 more
openaire   +3 more sources