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The influence of p-terphenyl polyketides 1–3 from Aspergillus candidus KMM 4676 and cerebroside flavuside B (4) from Penicillium islandicum (=Talaromyces islandicus) against the effect of neurotoxins, rotenone and paraquat, on Neuro-2a cell viability by ...
Ekaterina A. Yurchenko +7 more
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Cerebrosides are glycosylated sphingolipids, and in mammals they contribute to the pro-/anti-inflammatory properties and innate antimicrobial activity of the skin and mucosal surfaces.
Ekaterina A. Chingizova +9 more
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Calcifediol: Mechanisms of Action
Due to its essential role in calcium and phosphate homeostasis, the secosteroid hormone calcitriol has received growing attention over the last few years. Calcitriol, like other steroid hormones, may function through both genomic and non-genomic mechanisms.
Simone Donati +7 more
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The use and mechanism of action of terbinafine compared to other antifungal drugs used in the pharmacotherapy of candidiasis [PDF]
Terbinafine as an antifungal drug was introduced to the world market in 1991, which was a great advance in dermatology. From that time to 1999, it was used orally with good results in over 10 million people and locally in over 30 million.
Piotr Mariusz Dwiecki +2 more
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The rise in antibiotic-resistant strains of clinically important pathogens is a major threat to global health. The World Health Organization (WHO) has recognized the urgent need to develop alternative treatments to address the growing list of priority ...
Karyne Rangel +4 more
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The results of an investigation of the protective effects of five lanostane triterpenoids: 3β-acetoxy-7β,8β-epoxy-5α-lanost-24-en-30,9α-olide (1), 3β-hydroxy-7β,8β-epoxy-5α-lanost-24-en- 30,9α-olide (2), 29-nor-penasterone (3), penasterone (4), and ...
Ekaterina A. Yurchenko +6 more
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Background Persons with disabilities can have physical, mental, intellectual, or sensory impairments which can hinder their social participation. Despite Sustainable Development Goals call for “universal access to sexual and reproductive health (SRH ...
Rupa Shiwakoti +6 more
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The Manuscript titled "Mechanism of Action p53" was retracted on 02-08-2023 based on author request to prevent repeated publication.
Ghorbat Saleh Ali
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Bisphosphonates: Mechanisms of Action [PDF]
The geminal bisphosphonates are a class of drug, developed in the last 30 years, characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical effect on
openaire +2 more sources
A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and ...
Irina Bakunina +8 more
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