Results 291 to 300 of about 4,146,035 (404)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Correction: Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice. [PDF]

BMC Vet Res
Gao H, Xu Q, Zhu J, Kuerban K, Chen B, Zhao J, Aimulajiang K, Teng L.   +7 more
europepmc   +1 more source

Studies on the Mechanism of Action of Preservatives. I

, 1951
Kinjiro Yamada
openalex   +2 more sources

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Dual Modulation of Autophagy and Apoptosis as Anticancer Mechanism of Action of <i>Khaya grandiofoliola</i> in Colon Carcinoma Cells. [PDF]

Int J Mol Sci
Anifowose SO, Oladejo MK, Salih AM, Almutairi LM, Almansour MI, Al-Dahmash B, Al Mosallam MS, Alanazi IO, Rady A.   +8 more
europepmc   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Insights into the cellular function and mechanism of action of quinone reductase 2 (NQO2). [PDF]

Biochem J
Islam F, Shilton B.
europepmc   +1 more source

Selective Inhibitory Action of Colored Light upon the Retinal Color Processes and its Usefulness for Analysis of the Mechanism of Color Reception

, 1950
Köiti Motokawa
openalex   +2 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

An Evaluation of the Anti-Rabies Effect of Bufotenine in Murine Rabies Models to Determine Its Mechanism of Action. [PDF]

Viruses
Pereira PMC, Silva ACR, Asano KM, da Costa Neves A, Sciani JM, Pimenta DC, Vigerelli H.   +6 more
europepmc   +1 more source