Results 51 to 60 of about 3,894,411 (305)

MECHANISM OF ACTIONS OF ANTIDEPRESSANTS: BEYOND THE RECEPTORS

Psychiatry and Clinical Psychopharmacology, 2021
Since the discovery of first antidepressants-monoamine oxidase inhibitors- a half century passed. There are now almost twodozen antidepressant agents that work by nine distinct pharmacological mechanisms at the receptor level.
Ayşegül Yıldız, Ali Saffet Gönül, Lut Tamam   +2 more
doaj  

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Sulodexide. Pharmacokinetics, pharmacodynamics, and mechanism of action

Clinical Management Issues, 2015
Sulodexide is a highly purified preparation containing glycosaminoglycans composed from heparin-like and dermatan fractions. It is similar to unfractionated heparin, but it shows a prolonged half-life, a higher bioavability and a reduced effect on ...
Luca Masotti
doaj   +1 more source

The Study of Methodology of Formation of the Complex Mechanism of Strategic Management of Building Enterprise [PDF]

, 2016
Strategic objectives and principles that support them should automatically transform into a company concept, detail its status, express intent of the owner and management of the company, when working with customers and the public.
Kononova, O. (Oleksandra)
core   +2 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Antidepressant-like effects of gallic acid: dual effect on serotonergic and catecholaminergic neurotransmissions

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, is a phenolic acid derivative and a natural polyphenol found in tea leaves, grapes, berries and plants like Thuja, Quercus, Rhus, Camelia.
Nazli Turan, Ozgur Devrim Can, Yusuf Ozturk   +2 more
doaj  

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A New Approach to Non-Commutative U(N) Gauge Fields

, 2010
Based on the recently introduced model of arXiv:0912.2634 for non-commutative U(1) gauge fields, a generalized version of that action for U(N) gauge fields is put forward. In this approach to non-commutative gauge field theories, UV/IR mixing effects are
Armoni A., Attems M., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N., Blaschke D. N. Kronberger E. Sedmik R. I. P. Wohlgenannt M., Blaschke D. N. Rofner A. Sedmik R. I. P. Wohlgenannt M., D. N. Blaschke, Grosse H., Hayakawa M., Levell J., Matusis A., Minwalla S., Rivasseau V., Vilar L. C. Q.   +16 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source