Results 71 to 80 of about 4,146,035 (404)
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action
Journal of Pharmacology and Experimental Therapeutics, 2019 For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to avoid the limiting side effects of dopamine receptor blockade, has failed to date ...
N. Dedic +11 more
semanticscholar +1 more source
Oritavancin: Mechanism of Action [PDF]
Clinical Infectious Diseases, 2012 Oritavancin is a semisynthetic lipoglycopeptide analogue of vancomycin that contains the heptapeptide core common to all glycopeptides. It differs from vancomycin by the presence of a hydrophobic N-4-(4-chlorophenyl)benzyl (also referred to as 4'-chlorobiphenylmethyl) substituent on the disaccharide sugar, the addition of a 4-epi-vancosamine ...
George G. Zhanel +2 more
openaire +3 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Molecular Architecture and Biological Reactions [PDF]
, 1946 Answers to many basic problems of biology—nature of growth, mechanism of duplication of viruses and genes , action of enzymes, mechanism, of physiological activity of drugs, hormones, and vitamins, structure and action of nerve and brain tissue—may ...
Pauling, Linus
core
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate). [PDF]
, 2019 Chronic kidney disease (CKD) is a major cause of morbidity and premature mortality and represents a significant global public health issue. Underlying this burden are the many complications of CKD, including mineral and bone disorders, anemia, and ...
Bino, Avi +2 more
core
Mechanism of action of interferon-tau in the uterus during early pregnancy.
Journal of reproduction and fertility. Supplement, 2019 Early pregnancy is maintained in ruminants through the actions of conceptus-derived interferon (IFN)-tau on the endometrium. IFN-tau alters uterine release of PGF2 alpha' which results in rescue of the corpus luteum and continued release of progesterone.
T. Hansen +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
The Study of Methodology of Formation of the Complex Mechanism of Strategic Management of Building Enterprise [PDF]
, 2016 Strategic objectives and principles that support them should automatically transform into a company concept, detail its status, express intent of the owner and management of the company, when working with customers and the public.
Kononova, O. (Oleksandra)
core +2 more sources
Traditional Chinese Medicine for Breast Cancer: A Review
Breast Cancer: Targets and Therapy, 2023 Rui-Qi Feng,1 De-Hui Li,2 Xu-Kuo Liu,1 Xiao-Hui Zhao,1 Qian-Er Wen,1 Ying Yang1 1Graduate School of Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, People’s Republic of China; 2Oncology Department II, the First Affiliated Hospital of ...
Feng RQ +5 more
doaj