Results 41 to 50 of about 22,796,869 (307)

A neural-mechanistic hybrid approach improving the predictive power of genome-scale metabolic models

bioRxiv, 2022
Constraint-based metabolic models have been used for decades to predict the phenotype of microorganisms in different environments. However, quantitative predictions are limited unless labor-intensive measurements of media uptake fluxes are performed.
L. Faure, Bastien Mollet, Wolfram Liebermeister, J. Faulon   +3 more
semanticscholar   +1 more source

Recovery in environmental risk assessments at EFSA

EFSA Journal, 2016
EFSA performs environmental risk assessments (ERAs) for single potential stressors such as plant protection products, genetically modified organisms and feed additives and for invasive alien species that are harmful for plant health.
EFSA Scientific Committee
doaj   +1 more source

Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection

Signal Transduction and Targeted Therapy, 2020
Dear Editor , Drug repurposing is a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent, as is the case of emerging pathogens.
C. Loucera, M. Esteban-Medina, Kinza Rian, M. M. Falco, J. Dopazo, M. Peña-Chilet   +5 more
semanticscholar   +1 more source

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative Disease

Frontiers in Neuroscience, 2022
Through advances in the past decades, the central role of aberrant protein aggregation has been established in many neurodegenerative diseases. Crucially, however, the molecular mechanisms that underlie aggregate proliferation in the brains of affected ...
Georg Meisl, Tuomas P. J. Knowles, Tuomas P. J. Knowles, David Klenerman, David Klenerman   +4 more
doaj   +1 more source

Knowledge-based vision and simple visual machines [PDF]

, 1997
The vast majority of work in machine vision emphasizes the representation of perceived objects and events: it is these internal representations that incorporate the 'knowledge' in knowledge-based vision or form the 'models' in model-based vision. In this
Dave Cliff, H. B. Barlow, Harvey I., J. Anderson, Lee D. N., Lee D. N., Lee D. N., Nelson R. C., Noble Jason, R. L. Gregory, Taylor A.   +10 more
core   +4 more sources

A scoping review of side-dress nitrogen recommendation systems and their perspectives in precision agriculture

Italian Journal of Agronomy, 2021
A scoping review of the relevant literature was carried out to identify the existing N recommendation systems, their temporal and geographical diffusion, and knowledge gaps. In total, 151 studies were identified and categorized.
Martina Corti, Virginia Fassa, Luca Bechini   +2 more
doaj   +1 more source

Hitting the sweet spot of complexity: Reasons why the development of new custom-tailored models is still warranted and should be encouraged in aquatic sciences

Journal of Limnology, 2021
Process-based aquatic ecosystem models are increasingly being developed and used in freshwater ecology and other aquatic sciences, as they are powerful tools to gain a mechanistic understanding of ecological processes and inform policy and decision ...
Gregorio A. López Moreira M., Marco Toffolon, Franz Hölker   +2 more
doaj   +1 more source

The Evolution of Chromosome Numbers: Mechanistic Models and Experimental Approaches

Genome Biology and Evolution, 2020
Chromosome numbers have been widely used to describe the most fundamental genomic attribute of an organism or a lineage. Although providing strong phylogenetic signal, chromosome numbers vary remarkably among eukaryotes at all levels of taxonomic ...
I. Mayrose, M. Lysak
semanticscholar   +1 more source

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

CPT: Pharmacometrics & Systems Pharmacology, 2021
The value of in silico methods in drug development and evaluation has been demonstrated repeatedly and convincingly. While their benefits are now unanimously recognized, international standards for their evaluation, accepted by all stakeholders involved,
F. Musuamba, Ine Skottheim Rusten, R. Lesage, G. Russo, R. Bursi, L. Emili, Gaby Wangorsch, E. Manolis, K. Karlsson, A. Kulesza, E. Courcelles, J. Boissel, C. F. Rousseau, E. Voisin, R. Alessandrello, Nuno Curado, E. Dall’Ara, B. Rodríguez, F. Pappalardo, L. Geris   +19 more
semanticscholar   +1 more source

A reaction-diffusion predator-prey model with pursuit, evasion, and nonlocal sensing

Mathematical Biosciences and Engineering, 2019
In this paper, we propose and analyze a reaction-diffusion model for predator-prey interaction, featuring both prey and predator taxis mediated by nonlocal sensing. Both predator and prey densities are governed by parabolic equations.
Paulo Amorim, Bruno Telch , Luis M. Villada   +2 more
doaj   +1 more source