Results 81 to 90 of about 66,500 (291)

Roles of mechanistic target of rapamycin and transforming growth factor-B signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis [PDF]

, 2016
Molting in decapod crustaceans is controlled by molt-inhibiting hormone (MIH), an eyestalk neuropeptide that suppresses production of ecdysteroids by a pair of molting glands (Y-organs or YOs). Eyestalk ablation (ESA) activates the YOs, which hypertrophy
Abuhagr, Ali M., Chang, Ernest S., Chang, Sharon A., MacLea, Kyle S., Mudron, Megan R., Mykles, Donald L.   +5 more
core   +2 more sources

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
core   +2 more sources

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

GeroScience, 2020
Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway.
Mota Martorell, Natàlia, Jové Font, Mariona, Pradas Barriga, Irene, Berdún Hernández, Rebeca, Sanchez, Isabel, Naudí i Farré, Alba, Garí Marsol, Eloi, Barja, Gustavo, Pamplona Gras, Reinald   +8 more
openaire   +3 more sources

The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity

Cell Regeneration, 2023
A better understanding of how and why the regenerative capacity differs among species will not only provide insights into the regeneration process but also hold value for the development of regenerative medicine and the improvement of healing procedures.
Hanyu Dou, Jianzhou Li, Taomin Huang, Xiaolei Ding   +3 more
doaj   +1 more source

Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival [PDF]

, 2016
As a critical regulator of cell growth, the mechanistic target of rapamycin (mTOR) protein operates as part of two molecularly and functionally distinct complexes. Herein, we demonstrate that mTOR complex molecular composition varies in different somatic
Gutmann, David H, Smithson, Laura J
core   +2 more sources

Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows

Animal
Sulphate plays a vital role in the growth and development of the foetus. Sodium sulphate (Na2SO4) is utilised as a dietary protein nutrient factor and helps replenish sulphur elements in livestock and poultry.
R. Zhou, L. Zhe, S.S. Lai, H.M. Wen, L. Hu, X.L. Zhang, Y. Zhuo, S.Y. Xu, Y. Lin, B. Feng, L.Q. Che, D. Wu, Z.F. Fang   +12 more
doaj   +1 more source

Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins. [PDF]

BMC Dev Biol, 2014
The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF), Notch, retinoic acid, and Wnt, are ...
Hirose K, Shiomi T, Hozumi S, Kikuchi Y.
europepmc   +6 more sources

Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors. [PDF]

, 2016
Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer.
Demartines, N., Dormond, O., Duval, A.P., Faes, S., Horlbeck, J., Letovanec, I., Planche, A., Pythoud, C., Riggi, N., Santoro, T., Stehle, J.C., Uldry, E.   +11 more
core   +1 more source

Resolution of depression: Antidepressant actions of resolvins

Neuroscience Research
Major depressive disorder, one of the most widespread mental illnesses, brings about enormous individual and socioeconomic consequences. Conventional monoaminergic antidepressants require weeks to months to produce a therapeutic response, and ...
Satoshi Deyama, Katsuyuki Kaneda, Masabumi Minami   +2 more
doaj   +1 more source

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]

, 2014
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen, Cross, D. Grahame Hardie, Dagon, Dale, Davidson, Davies, Davies, Decensi, Evans, Faubert, Fiona A. Ross, Fogarty, Frame, Goransson, Gowans, Graeme J. Gowans, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Hawley, Hirai, Horman, Hurley, Hurley, Ji, Lee, Lizcano, Mankouri, Nicholas R. Leslie, Ning, Obata, Obenauer, Priyanka Tibarewal, Roach, Sanchez-Cespedes, Sanders, Scott, Shaw, Simon A. Hawley, Street, Suzuki, Towler, Wingo, Woods, Woods, Woods, Woods, Xiao, Xiao, Yuan   +53 more
core   +4 more sources