Results 1 to 10 of about 11,546 (99)

Nuclear mechanobiology rules immune cells’ functions: from differentiation to cell trafficking and pathogen killing [PDF]

Nucleus
The immune system functions within tissue microenvironments of mechanical and geometrical constraints. Within these constraints, immune cells must rapidly move and execute effector functions to regulate innate and adaptive immunity.
Jörg Renkawitz, Allen Yesin, Janina Kroll, Aidan T. Cabral, Sarah D’Annunzio, Hawa Racine Thiam   +5 more
doaj   +2 more sources

Perspectives on in silico bone mechanobio [PDF]

European Cells & Materials, 2022
Bone mechanobiology is the study of the physical, biological and mechanical processes that continuously affect the multiscale multicellular system of the bone from the organ to the molecular scale.
D Boaretti, E Wehrle, YD Bansod, DC Tourolle né Betts, R Müller   +4 more
doaj   +1 more source

Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives

Nature Communications, 2023
In this work, the authors identify regulators of actin filament assembly involved in chiral organisation of the actin cytoskeleton in single cells and chiral alignment of cells in groups.
Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F. H. Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D. Bershadsky   +15 more
doaj   +1 more source

Simple yet effective methods to probe hydrogel stiffness for mechanobiology

Scientific Reports, 2021
In spite of tremendous advances made in the comprehension of mechanotransduction, implementation of mechanobiology assays remains challenging for the broad community of cell biologists.
Alessandro Gandin, Yaswanth Murugesan, Veronica Torresan, Lorenzo Ulliana, Anna Citron, Paolo Contessotto, Giusy Battilana, Tito Panciera, Maurizio Ventre, A. Paolo Netti, Lucia Nicola, Stefano Piccolo, Giovanna Brusatin   +12 more
doaj   +1 more source

Mechanobiology of the female reproductive system

Reproductive Medicine and Biology, 2021
Background Mechanobiology in the field of human female reproduction has been extremely challenging technically and ethically. Methods The present review provides the current knowledge on mechanobiology of the female reproductive system.
Sachiko Matsuzaki
doaj   +1 more source

Proteo-transcriptomics meta-analysis identifies SUMO2 as a promising target in glioblastoma multiforme therapeutics

Cancer Cell International, 2021
Highlights The major highlights of this study are as follows: Key upregulated hub kinases and coding genes in GBM are found to be targets of SUMO2 conjugation.
Aswani P. Krishna, Sebastian John, Puja Laxmanrao Shinde, Rashmi Mishra   +3 more
doaj   +1 more source

Actomyosin contractility as a mechanical checkpoint for cell state transitions

Scientific Reports, 2022
Cell state transitions induced by mechano-chemical cues result in a heterogeneous population of cell states. While much of the work towards understanding the origins of such heterogeneity has focused on the gene regulatory mechanisms, the contribution of
Saradha Venkatachalapathy, Dyuthi Sreekumar, Prasuna Ratna, G. V. Shivashankar   +3 more
doaj   +1 more source

Enhanced tumor cell killing by ultrasound after microtubule depolymerization

Bioengineering & Translational Medicine, 2021
Recent studies show that tumor cells are vulnerable to mechanical stresses and undergo calcium‐dependent apoptosis (mechanoptosis) with mechanical perturbation by low‐frequency ultrasound alone.
Aditi Singh, Ajay Tijore, Felix Margadant, Chloe Simpson, Deepak Chitkara, Boon Chuan Low, Michael Sheetz   +6 more
doaj   +1 more source

An integrated enhancement and reconstruction strategy for the quantitative extraction of actin stress fibers from fluorescence micrographs

BMC Bioinformatics, 2017
Background The stress fibers are prominent organization of actin filaments that perform important functions in cellular processes such as migration, polarization, and traction force generation, and whose collective organization reflects the physiological
Zhen Zhang, Shumin Xia, Pakorn Kanchanawong   +2 more
doaj   +1 more source

From cellular to molecular mechanobiology

APL Bioengineering, 2020
Mechanobiology at the cellular level is concerned with what phenotypes that cells exhibit to maintain homeostasis in their normal physiological mechanical environment, as well as what phenotypical changes that cells have to make when their environment is
Cheng Zhu, Cho-yin Lee, Larry V. McIntire   +2 more
doaj   +1 more source