Results 91 to 100 of about 11,668 (212)
Responsive Materials, EarlyView.This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of ...
Ruth M. C. Verbroekken +2 more
wiley +1 more source
Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation
Small, EarlyView.A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul +8 more
wiley +1 more source
Nature CommunicationsChromatin organization regulates gene expression, with nanoscale heterochromatin domains playing a fundamental role. Their size varies with microenvironmental stiffness and epigenetic interventions, but how these factors regulate their formation and ...
Vinayak Vinayak +7 more
doaj +1 more source
Small, EarlyView.This work demonstrates a new thermophoretic strategy to fabricate fluorescently labeled stiffness gradient hydrogels, enabling contactless stiffness characterization. Fibroblasts cultured on gradient GelMA and Gellan gum hydrogels revealed distinct cell morphology and migration behavior.
Shin Wei Chong +8 more
wiley +1 more source
Mechanobiology in Stem Cell‐Based Bioprinting
Cell Proliferation, EarlyView.Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
APL BioengineeringHow forces and mechanics influence and regulate living cells remains elusive. Mechanomemory, the response to a mechanical perturbation that persists after the perturbation is removed, is believed to be a key to understanding the impact of forces and ...
Fazlur Rashid +3 more
doaj +1 more source
Beyond the chaos: How architecture structures tumour biology
The FEBS Journal, EarlyView.Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner +3 more
wiley +1 more source
Piezo1-Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Melica ME +3 more
europepmc +2 more sources