Results 21 to 30 of about 11,668 (212)

mDia1 senses both force and torque during F-actin filament polymerization

Nature Communications, 2017
Formins are actin-polymerisation factors that are sensitive to force. Here the authors find that pulling force on an actin filament promoted faster actin polymerisation by the formin mDia1, and also found that the actin filament must be torsionally ...
Miao Yu, Xin Yuan, Chen Lu, Shimin Le, Ryo Kawamura, Artem K. Efremov, Zhihai Zhao, Michael M. Kozlov, Michael Sheetz, Alexander Bershadsky, Jie Yan   +10 more
doaj   +1 more source

FRET and mechanobiology [PDF]

Integrative Biology, 2009
Since the development of green fluorescent protein (GFP) and other fluorescent proteins (FPs) with distinct colors, genetically-encoded probes and biosensors have been widely applied to visualize the molecular localization and activities in live cells.
Yingxiao, Wang, Ning, Wang
openaire   +2 more sources

Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset

Nature Communications, 2018
Germline cells in many species are fused to form a syncytium but the mechanics behind the maintenance of these structures are poorly defined. Here, the authors propose an inner contractile actomyosin corset provides a supportive framework to maintain ...
Agarwal Priti, Hui Ting Ong, Yusuke Toyama, Anup Padmanabhan, Sabyasachi Dasgupta, Matej Krajnc, Ronen Zaidel-Bar   +6 more
doaj   +1 more source

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

Frontiers in Pharmacology, 2022
Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation.
Yingqi Zhang, Yingqi Zhang, Yingqi Zhang, Fengtao Jiang, Yunfeng Chen, Yunfeng Chen, Lining Arnold Ju, Lining Arnold Ju, Lining Arnold Ju   +8 more
doaj   +1 more source

Stem cell mechanobiology [PDF]

Journal of Cellular Biochemistry, 2011
AbstractStem cells are undifferentiated cells that are capable of proliferation, self‐maintenance and differentiation towards specific cell phenotypes. These processes are controlled by a variety of cues including physicochemical factors associated with the specific mechanical environment in which the cells reside.
Lee, David A., Knight, Martin M., Campbell, Jonathan J., Bader, Dan L.   +3 more
openaire   +4 more sources

Mechanobiology

International Journal For Multidisciplinary Research
Mechanobiology is an emerging field of multidisciplinary research studying how the physical properties of the cell environment and mechanical loads regulate biological processes at the cellular, tissue, and molecular levels. It adopts ideas from physics, biology, and engineering to comprehend how cells sense, translate, and respond to mechanical ...
Magham Ramachandra, Shaik Ul Haq, Dornala Dixit   +2 more
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Optogenetic control of YAP can enhance the rate of wound healing

Cellular & Molecular Biology Letters, 2023
Background Tissues need to regenerate to restore function after injury. Yet, this regenerative capacity varies significantly between organs and between species.
Pearlyn Jia Ying Toh, Marius Sudol, Timothy Edward Saunders   +2 more
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Mechanobiology of the meniscus [PDF]

Journal of Biomechanics, 2015
The meniscus plays a critical biomechanical role in the knee, providing load support, joint stability, and congruity. Importantly, growing evidence indicates that the mechanobiologic response of meniscal cells plays a critical role in the physiologic, pathologic, and repair responses of the meniscus.
McNulty, Amy L, Guilak, Farshid
openaire   +2 more sources

Elastomeric Pillar Cages Modulate Actomyosin Contractility of Epithelial Microtissues by Substrate Stiffness and Topography

Cells, 2023
Cell contractility regulates epithelial tissue geometry development and homeostasis. The underlying mechanobiological regulation circuits are poorly understood and experimentally challenging.
Lisann Esser, Ronald Springer, Georg Dreissen, Lukas Lövenich, Jens Konrad, Nico Hampe, Rudolf Merkel, Bernd Hoffmann, Erik Noetzel   +8 more
doaj   +1 more source

Novel localization of formin mDia2: importin β-mediated delivery to and retention at the cytoplasmic side of the nuclear envelope

Biology Open, 2015
The formin family proteins are important regulators of actin polymerization that are involved in many cellular processes. However, little is known about their specific cellular localizations.
Xiaowei Shao, Keiko Kawauchi, G. V. Shivashankar, Alexander D. Bershadsky   +3 more
doaj   +1 more source