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Cellular Basis of Mechanotransduction
The Biological Bulletin, 1998Physical forces, such as those due to gravity are fundamental regulators of tissue development. To influence morphogenesis, mechanical forces must alter growth and function. Yet little is known about how cells convert mechanical signals into a chemical response.
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Review of cellular mechanotransduction on micropost substrates
Medical & Biological Engineering & Computing, 2015As physical entities, living cells can sense and respond to various stimulations within and outside the body through cellular mechanotransduction. Any deviation in cellular mechanotransduction will not only undermine the orchestrated regulation of mechanical responses, but also lead to the breakdown of their physiological function.
Yuxu Geng, Zhanjiang Wang
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Role of vinculin in cellular mechanotransduction
Cell Biology International, 2016AbstractCell–matrix adhesion and cell–cell contacts are essential for the metabolism, protein synthesis, survival, and cancer metastasis of cells. Major transmembrane receptors are the integrins, which are responsible for cell–matrix adhesions, and the cadherins, which are important for cell–cell adhesions.
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Cellular mechanisms involved in mechanotransduction
Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. No.99CH37015), 2003Fluid flow induces increased c-fos and COX-2 expression in MC3T3-E1 cells that is dependent on flow-induced actin stress fiber formation(ASFF). The roles of intracellular Ca/sup 2+/ ([Ca/sup 2+/]) and Ca/sup 2+/ channels in these responses were examined using agents that alter [Ca/sup 2+/]/sub i/, release and Ca/sup 2+/ entry.
R. Duncan +5 more
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TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION
Annual Review of Physiology, 1997▪ Abstract Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g.
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2009
'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of ...
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'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of ...
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Systems analysis of bone mechanotransduction at cellular level
2008 8th IEEE International Conference on BioInformatics and BioEngineering, 2008A dasiasystems-levelpsila computational modeling approach is implemented to study the mechano-regulation of bone at cellular level. Issues addressed using this approach include - determining the intra-cellular response of bone cells to mechanical stimulus, bone response to different mechanical loading conditions, the role of intra-cellular feedback ...
Kalyan C. Mynampati, Peter Lee Vee Sin
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Cellular Mechanisms of Mechanotransduction in Bone
2010Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in mechanical load. This adaptive ability is critical to skeletal development and maintenance of optimal skeletal health throughout life. Imbalances in the ability of bone to keep pace with demands placed on it by mechanical loading results in bone that is fragile and ...
Suzanne R.L. Young, Fredrick M. Pavalko
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Functional coupling of ion channels in cellular mechanotransduction
Biochemical and Biophysical Research Communications, 2014The major players in the processes of cellular mechanotransduction are considered to be mechanosensitive (MS) or mechano-gated ion channels. Non-selective Ca(2+)-permeable channels, whose activity is directly controlled by membrane stretch (stretch-activated channels, SACs) are ubiquitously present in mammalian cells of different origin.
Vladislav I, Chubinskiy-Nadezhdin +2 more
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Biomaterials for Studies in Cellular Mechanotransduction
2011The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors.
Ross De Volder, Hyunjoon Kong
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