Results 251 to 260 of about 1,871,467 (288)
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TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION
Annual Review of Physiology, 1997▪ Abstract Physical forces of gravity, hemodynamic stresses, and movement play a critical role in tissue development. Yet, little is known about how cells convert these mechanical signals into a chemical response. This review attempts to place the potential molecular mediators of mechanotransduction (e.g.
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Functional coupling of ion channels in cellular mechanotransduction
Biochemical and Biophysical Research Communications, 2014The major players in the processes of cellular mechanotransduction are considered to be mechanosensitive (MS) or mechano-gated ion channels. Non-selective Ca(2+)-permeable channels, whose activity is directly controlled by membrane stretch (stretch-activated channels, SACs) are ubiquitously present in mammalian cells of different origin.
Vladislav I, Chubinskiy-Nadezhdin +2 more
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Microengineering tools to study cellular mechanotransduction
Bio-, Micro-, and Nanosystems (IEEE Cat. No.03EX733), 2004Cells respond to many signals from their local environment, as a result of contact with solid-state surfaces, soluble agents, neighboring cells, and mechanical forces. We are investigating the interactions between these signals to understand how cells integrate the mechanical and biochemical signals in regulating endothelial cell function.
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Biomaterials for Studies in Cellular Mechanotransduction
2011The conversion of mechanical stimuli into chemical signals is of the utmost importance for developmental and normal physiology. Mechanotransduction plays a pivotal role in regulating cellular function and, subsequent tissue maintenance and repair, apoptosis, and many other physiological functions, coupled with a broad array of soluble factors.
Ross De Volder, Hyunjoon Kong
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Cellular Mechanisms of Mechanotransduction in Bone
2010Bone is a dynamic tissue that adjusts its structure over time to adapt to changes in mechanical load. This adaptive ability is critical to skeletal development and maintenance of optimal skeletal health throughout life. Imbalances in the ability of bone to keep pace with demands placed on it by mechanical loading results in bone that is fragile and ...
Suzanne R.L. Young, Fredrick M. Pavalko
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Cellular mechanotransduction: putting all the pieces together again
The FASEB Journal, 2006Analysis of cellular mechanotransduction, the mechanism by which cells convert mechanical signals into biochemical responses, has focused on identification of critical mechanosensitive molecules and cellular components. Stretch‐activated ion channels, caveolae, integrins, cadherins, growth factor receptors, myosin motors ...
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Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.
BiomaterialsEngineered matrices provide a valuable platform to understand the impact of biophysical factors on cellular behavior such as migration, proliferation, differentiation, and tissue remodeling, through mechanotransduction.
Anna L. Kersey +12 more
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Nuclear envelope proteins, mechanotransduction, and their contribution to breast cancer progression
npj Biological Physics and MechanicsBreast cancer cells frequently exhibit changes in the expression of nuclear envelope (NE) proteins such as lamins and emerin that determine the physical properties of the nucleus and contribute to cellular mechanotransduction.
Sarah Henretta, J. Lammerding
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