Results 201 to 210 of about 39,386 (288)

Leveraging Electrochemical Diversity in Engineering Liquid‐State Ionic Devices for Neuromorphic Computing

Small, EarlyView.
Mixed‐ion transport through Å‐scale pores exhibits various functions, including voltage activation, voltage inactivation, nanopulse generation, and synaptic behavior. Our work reveals that one of the fundamental advantages of ionic computing over electronic computingthe diversity of charge carriersdirectly translates into functional diversity in the ...
Yechan Noh, Alex Smolyanitsky
wiley   +1 more source

Blood Mechanical Intelligence: From Force Sensing to Precision Mechanomedicine. [PDF]

Research (Wash D C)
Wang S, Pan T, Liu Q, Li Z, Wen T, Cheng B, Xu F, Yao C.   +7 more
europepmc   +1 more source

Penile traction therapy after radical pelvic surgery: Does it work?

UroPrecision, EarlyView.
Abstract Sexual dysfunction, including erectile dysfunction and penile shortening, is a frequent consequence of radical pelvic surgeries such as prostatectomy, cystoprostatectomy, and rectal cancer surgery. These complications primarily result from nerve injury and hypoxia‐induced corporal fibrosis.
Ahmet Tevfik Albayrak, Mustafa Faruk Usta   +1 more
wiley   +1 more source

Decoding Dual Regulatory Layers: Integrating Differential Expression and Alternative Splicing Dynamics in the Evolution of Laryngeal Echolocation Across Chiropteran Lineages

Integrative Zoology, EarlyView.
We integrated short‐read and long‐read RNA‐seq data from cochlear tissues of echolocating and non‐echolocating bats to disentangle transcriptional and post‐transcriptional regulation. Echolocating bats showed neural‐function enrichment among differentially expressed genes, while alternatively spliced genes were linked to epigenetic regulation. Overlaps
Jianyu Wu, Daoyuan Hu, Min Chen, Xiuguang Mao   +3 more
wiley   +1 more source

A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease. [PDF]

Adv Respir Med
Tugade C, Ramis J.
europepmc   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Improving Nonviral Gene Delivery by Activating Mechanosensing-Dependent Endocytic Pathways. [PDF]

ACS Appl Mater Interfaces
Fruzzetti F, Ruzzante B, Giagnorio E, Bonanno S, Lauria Pinter G, Marcuzzo S, Candiani G, Bono N.   +7 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Neuromechanobiology: Bridging Mechanobiology and Neuroscience Through Evidence and Open Questions. [PDF]

Cells
Zimkowska K, Riu-Villanueva M, Del Río JA.   +2 more
europepmc   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source