Results 231 to 240 of about 40,337 (298)

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms. [PDF]

NPJ Microgravity
Tosi DD, Tiberio F, Di Pietro L, Polito L, Parolini O, Minotti A, Arcovito A, Lattanzi W.   +7 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Idiopathic pulmonary fibrosis from a multiscale mechanobiology perspective: Mechanisms and future therapeutic prospects. [PDF]

iScience
Xia T, Wang X, Yang Z, Zhao R.
europepmc   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Blood Mechanical Intelligence: From Force Sensing to Precision Mechanomedicine. [PDF]

Research (Wash D C)
Wang S, Pan T, Liu Q, Li Z, Wen T, Cheng B, Xu F, Yao C.   +7 more
europepmc   +1 more source

Simultaneous tibial and fibular sesamoid bone stress injuries in a collegiate volleyball player: The role of shockwave therapy in recovery and return to sport

PM&R, EarlyView.
Bridget M. Doyle, Nader F. Elkabbani, Farah Hussain, Mason W. Briles, Rosa M. Pasculli   +4 more
wiley   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Improving Nonviral Gene Delivery by Activating Mechanosensing-Dependent Endocytic Pathways. [PDF]

ACS Appl Mater Interfaces
Fruzzetti F, Ruzzante B, Giagnorio E, Bonanno S, Lauria Pinter G, Marcuzzo S, Candiani G, Bono N.   +7 more
europepmc   +1 more source