Results 251 to 260 of about 40,337 (298)
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Mechanisms of mechanotransduction and physiological roles of PIEZO channels
Nature Reviews Molecular Cell BiologyBailong Xiao
exaly +2 more sources
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction.
Trends in Cell Biology, 2023Mechanobiology studies the mechanisms by which cells sense and respond to physical forces, and the role of these forces in shaping cells and tissues themselves. Mechanosensing can occur at the plasma membrane, which is directly exposed to external forces,
Santosh Phuyal +3 more
semanticscholar +1 more source
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus
Nature Reviews Molecular Cell Biology, 2009Ning Wang, Donald E Ingber
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Annual Review of Biomedical Engineering, 2018
The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets.
Caroline E, Hansen +3 more
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The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets.
Caroline E, Hansen +3 more
openaire +2 more sources
Mechanotherapy in Oncology: Targeting Nuclear Mechanics and Mechanotransduction.
Advanced Drug Delivery Reviews, 2023Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence suggests that characteristic differences are present in the nuclear mechanics and mechanotransduction of cancer cells compared with those of normal cells.
Shaobao Liu +8 more
semanticscholar +1 more source
Multiscale Biomechanics and Mechanotransduction from Liver Fibrosis to Cancer.
Advanced Drug Delivery Reviews, 2022A growing body of multiscale biomechanical studies has been proposed to highlight the mechanical cues in the development of hepatic fibrosis and cancer.
Ning Li +6 more
semanticscholar +1 more source
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Science Translational Medicine, 2022Burns and other traumatic injuries represent a substantial biomedical burden. The current standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which frequently results in contractures, abnormal pigmentation, and loss of ...
Kellen Chen +30 more
semanticscholar +1 more source
Comprehensive Physiology, 2011
AbstractPhysical forces are central players in development and morphogenesis, provide an ever‐present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical environment into biochemical signals.
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AbstractPhysical forces are central players in development and morphogenesis, provide an ever‐present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical environment into biochemical signals.
openaire +2 more sources
Mechanotransduction in the pathogenesis of nonalcoholic fatty liver disease.
Journal of Hepatology, 2022Mechanobiology is a domain of interdisciplinary research that aims to explore the impact of physical force, applied externally or internally, on cell and tissue function, including development, growth, and differentiation.
Emilie K. Mitten, G. Baffy
semanticscholar +1 more source
Neurosensory mechanotransduction
Nature Reviews Molecular Cell Biology, 2009Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical signals. The proteins that transduce these signals and underlie these senses, however, are mostly unknown. Research over the past decade has suggested that members of three families of channel proteins are candidate transduction molecules.
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