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Molecular regulation of mechanotransduction
Biochemical and Biophysical Research Communications, 2005There is a common mechanism for mechanotransduction in cells, regardless of the cell type. Integrins, interacting with their matrix/environment, mediate increases in intracellular Ca2+ levels and activate MAP kinase cascades to cause ERK1/2 phosphorylation. Phosphorylated ERK1/2 causes the activation of the AP-1 family of transcription factors that are
Jameel, Iqbal, Mone, Zaidi
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Genetics of Sensory Mechanotransduction
Annual Review of Genetics, 2002▪ Abstract The molecular mechanisms for the transduction of light and chemical signals in animals are fairly well understood. In contrast, the processes by which the senses of touch, balance, hearing, and proprioception are transduced are still largely unknown.
Glen G, Ernstrom, Martin, Chalfie
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Neurosensory mechanotransduction
Nature Reviews Molecular Cell Biology, 2009Neurons that sense touch, sound and acceleration respond rapidly to specific mechanical signals. The proteins that transduce these signals and underlie these senses, however, are mostly unknown. Research over the past decade has suggested that members of three families of channel proteins are candidate transduction molecules.
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Mechanotransduction in Cardiac Myocytes
Annals of the New York Academy of Sciences, 2004Abstract: Cardiac myocytes react to diverse mechanical demands with a multitude of transient and long‐term responses to normalize the cellular mechanical environment. Several stretch‐activated signaling pathways have been identified, most prominently guanine nucleotide binding proteins (G‐proteins), mitogen‐activated protein kinases (MAPK), Janus ...
Jan, Lammerding +2 more
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Effect of aging on cellular mechanotransduction
Ageing Research Reviews, 2011 Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has ...
Miaozong Wu +2 more
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Mechanotransduction through the cytoskeleton
American Journal of Physiology-Cell Physiology, 2002We constructed a model cytoskeleton to investigate the proposal that this interconnected filamentous structure can act as a mechano- and signal transducer. The model cytoskeleton is composed of rigid rods representing actin filaments, which are connected with springs representing cross-linker molecules.
Yinon, Shafrir, Gabor, Forgacs
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The role of mechanotransduction in tendon
Journal of Bone and Mineral ResearchAbstract Tendons play an important role in the maintenance of motor function by connecting muscles and bones and transmitting forces. Particularly, the role of mechanical stress has primarily focused on the key mechanism of tendon homeostasis, with much research on this topic.
Ryo Nakamichi, Hiroshi Asahara
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Interactions of mechanotransduction pathways
Biorheology: The Official Journal of the International Society of Biorheology, 2003Integrins may serve as mechanosensors in endothelial cells (ECs): shear stress causes integrin–Shc association, assembly of the signaling complex and then leads to JNK activation. Flow also mediates selective and cell‐specific alterations in vascular cell G‐protein expression that correlate with changes in cell‐signalling, G ...
Vénus, Labrador +5 more
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Targeting mechanotransduction in osteosarcoma
Biochemical and Biophysical Research CommunicationsOsteosarcoma (OS) is a common primary bone malignancy predominantly affecting adolescents. The bone microenvironment is crucial in modulating the initiation and progression of OS. OS cells transduce mechanical signals into biochemical signals, thereby regulating cellular behavior.
Ruoyun He +6 more
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The mechanotransduction of blood pressure
Science, 2018Two stretch-activated channels in arteries could be targets for some types of heart ...
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