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Mechanotransduction in Cardiac Hypertrophy and Failure [PDF]
Circulation Research, 2015 Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load through a process known as mechanotransduction. In the heart, this process involves the conversion of mechanical stimuli into biochemical events that induce changes in
Robert C Lyon +2 more
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The role of the cell nucleus in mechanotransduction
Current Opinion in Cell Biology, 2020 © 2020 Elsevier Ltd. All rights reserved.Mechanical forces are known to influence cellular processes with consequences at the cellular and physiological level.
FRANCISCO J Calero-Cuenca, Edgar R Gomes
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Annual Review of Biomedical Engineering, 2018
The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets.
Caroline E, Hansen +3 more
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The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets.
Caroline E, Hansen +3 more
openaire +2 more sources
Mechanotransduction in adipocytes
Journal of Biomechanics, 2012Obesity is widely recognized as a major public health problem due to its strong association with a number of serious chronic diseases including hyperlipidemia, hypertension, type II diabetes and coronary atherosclerotic heart disease. During the development of obesity, the positive energy balance involves recruitment of new adipocytes from ...
Naama, Shoham, Amit, Gefen
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Comprehensive Physiology, 2011
Abstract Physical forces are central players in development and morphogenesis, provide an ever‐present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical ...
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Abstract Physical forces are central players in development and morphogenesis, provide an ever‐present backdrop influencing physiological functions, and contribute to a variety of pathologies. Mechanotransduction encompasses the rich variety of ways in which cells and tissues convert cues from their physical ...
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SnapShot: Mechanotransduction in the nucleus
Cell, 2022Cells are continuously exposed to tissue-specific extrinsic forces that are counteracted by cell-intrinsic force generation through the actomyosin cytoskeleton and alterations in the material properties of various cellular components, including the nucleus.
Fabien, Bertillot +2 more
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Epigenetic regulation of mechanotransduction
Nature Biomedical Engineering, 2021The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
Ryan Stowers, Ovijit Chaudhuri
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Mechanotransduction in gravisensing cells
Trends in Plant Science, 2003Plant organs can re-orientate themselves with respect to gravity. Gravisensing cells (statocytes) contain movable amyloplasts whose potential energy is apparently used to activate calcium channels by exerting tension on the actin network and/or pressure on the cytoskeleton elements lining the plasma membrane. The chain of events that follows remains to
Gérald, Perbal, Dominique, Driss-Ecole
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Mechanisms of Osteocyte Mechanotransduction
Clinical Reviews in Bone and Mineral Metabolism, 2010Healthy bones combine a proper resistance against fracture with a minimum use of material. This property is likely brought about by osteocytes in response to mechanical cues, but it is still unknown how whole bone loads are translated into a signal that can be sensed by the osteocytes.
Bakker, A.D., Klein Nulend, J.
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Current Opinion in Microbiology, 2017
Bacteria rapidly adapt to changes in their environment by leveraging sensing systems that permanently probe their surroundings. One common assumption is that such systems are responsive to signals that are chemical in nature. Yet, bacteria frequently experience changes in mechanical forces, for example as they transition from planktonic to sessile ...
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Bacteria rapidly adapt to changes in their environment by leveraging sensing systems that permanently probe their surroundings. One common assumption is that such systems are responsive to signals that are chemical in nature. Yet, bacteria frequently experience changes in mechanical forces, for example as they transition from planktonic to sessile ...
openaire +3 more sources