Results 151 to 160 of about 3,272 (188)
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Definitions, 2020
The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities.
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The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities.
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The Treatment of Mycosis Fungoides With Ointment-Based Mechlorethamine
Archives of Dermatology, 1982The use of topical mechlorethamine hydrochloride in the treatment of skin disease has been restricted because of the frequent development of contact dermatitis. A series of 24 patients with mycosis fungoides in stages 1A (eight patients), 1B (15 patients), and 2 (one patient) were treated with ointment-based mechlorethamine, prepared by an anhydrous ...
Norman M. Price +2 more
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Topical Use of Mechlorethamine in the Treatment of Psoriasis
Archives of Dermatology, 1972We have presented the results of treatment of 57 patients with psoriasis with topically applied mechlorethamine. Attempts to induce immunological tolerance to this chemical in 12 patients were unsuccessful. Although this is a useful treatment for psoriasis the high incidence of sensitization precludes its use until some method can be devised to prevent
Kenneth M. Halprin, J. Richard Taylor
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Topically Applied Mechlorethamine on 12 Dermatoses
Archives of Dermatology, 1962In 1959 remission occurred in a case of mycosis fungoides following the topical application of mechlorethamine hydrochloride (a nitrogen mustard) to the lesions. 1 Since then, mechlorethamine has been used topically in additional cases of mycosis fungoides and to treat several other dermatologic disorders.
John R. Haserick, James F. Madison
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Mechlorethamine-induced enhancement of radiation sensitivity of guanine
International Journal of Radiation Biology, 1996This study describes and characterizes the interactions of nitrogen mustard mechlorethamine (HN2) with guanine and the radiation sensitivity of guanine in the presence of HN2. Briefly, in an equimolar solution (0.5 mmol dm-3) the pH-dependence (pH 3.0-12.0) and time-dependence (0-36 h) of alkylation of guanine at room temperature were determined using ...
Y N Vaishnav, C E Swenberg
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Hypothermia Against Lethal Dose of Mechlorethamine
Archives of Surgery, 1961One of the problems involved in regional perfusion for cancer chemotherapy is protection of the bone marrow outside of the perfused area due to "leak" of the antitumor agent from the perfused area. Since in vitro experiments have shown that reduction in incubation temperature below 37 C depresses the antitumor effect of certain alkylating agents ...
Albert G. Smith, William W. Shingleton
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Biochemistry, 2016
Nitrogen mustard anticancer drugs generate highly reactive aziridinium ions that alkylate DNA. Monoadducts arising from reaction with position N7 of guanine residues are the major DNA adducts generated by these agents.
M. I. Nejad +3 more
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Nitrogen mustard anticancer drugs generate highly reactive aziridinium ions that alkylate DNA. Monoadducts arising from reaction with position N7 of guanine residues are the major DNA adducts generated by these agents.
M. I. Nejad +3 more
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Bone Marrow Protection in Mechlorethamine (Nitrogen Mustard) Therapy
Archives of Surgery, 1962The hematologic effects of mechlorethamine hydrochloride (nitrogen mustard) limit the dose employed when this drug is used for chemotherapy of advanced cancer. Although other toxicities are recognized, e.g., of the intestinal and central nervous system, they represent effects at higher dosage levels than are ordinarily used.
Walter Lawrence, Daniel G. Miller
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The Impact of Drug Shortages on Children with Cancer — The Example of Mechlorethamine
New England Journal of Medicine, 2012Among the generic drugs in short supply is mechlorethamine, part of a standard regimen for pediatric Hodgkin's lymphoma. The Pediatric Hodgkin Lymphoma Consortium has substituted cyclophosphamide, which is less effective and increases the risk of complications.
Monika L. Metzger +2 more
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Bioconjugate chemistry, 2018
Many strategies for the detection of nucleic acid sequence rely upon Watson-Crick hybridization of a probe strand to the target strand, but the reversible nature of nucleic acid hybridization presents an inherent challenge: short probes that provide high
Ruicheng Shi +4 more
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Many strategies for the detection of nucleic acid sequence rely upon Watson-Crick hybridization of a probe strand to the target strand, but the reversible nature of nucleic acid hybridization presents an inherent challenge: short probes that provide high
Ruicheng Shi +4 more
semanticscholar +1 more source