Results 31 to 40 of about 5,291 (227)

Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells

Chemical Research in Toxicology, 2019
Nitrogen mustard, mechlorethamine (bis(2-chloroethyl)methylamine; HN2), and sulfur mustard are potent vesicants that modify and disrupt cellular macromolecules including DNA leading to cytotoxicity and tissue injury.
Yi‐Hua Jan, Diane E. Heck, Debra L. Laskin, Jeffrey D. Laskin   +3 more
openalex   +3 more sources

Mechlorethamine

, 2006
James L. Schardein, Orest T. Macina
europepmc   +4 more sources

Topical mechlorethamine for cutaneous T-cell lymphoma: a historical perspective

EJC Skin Cancer
Balàzs Nagy, Norbert Kovács, Katinka Ónodi, Ildikó Csányi, Erika Varga, Henriette Ócsai, Judit Oláh, Rolland Gyulai, Eszter Baltás   +8 more
openalex   +2 more sources

Jak-STAT Inhibition Mediates Romidepsin and Mechlorethamine Synergism in Cutaneous T-Cell Lymphoma

Journal of Investigative Dermatology, 2021
José R. Cortés, Christina C. Patrone, S. Aidan Quinn, Yuhan Gu, Marta Sánchez-Martín, Adam L. Mackey, Anisha J. Cooke, Bobby B. Shih, Anouchka P. Laurent, Megan H. Trager, Adolfo A. Ferrando, Larisa J. Geskin, Teresa Palomero   +12 more
openalex   +3 more sources

Randomized Mechlorethamine/Chlormethine Induced Dermatitis Assessment Study (MIDAS) Establishes Benefit of Topical Triamcinolone 0.1% Ointment Cotreatment in Mycosis Fungoides

Dermatologic Therapy, 2022
Treatment of early-stage mycosis fungoides (MF) requires safe, skin-directed therapies. Medication side effects can lead to underutilization of effective therapies.
Carolina V Alexander-Savino, C. Chung, Elaine S. Gilmore, S. M. Carroll, B. Poligone   +4 more
semanticscholar   +1 more source

Phase 1 Dose Escalation of Single‐Agent Mechlorethamine in Dogs With Lymphoma [PDF]

Veterinary and Comparative Oncology
Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable.
Laura E. Chadsey, Paul R. Hess, Joanne L. Intile   +2 more
openalex   +2 more sources

Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model

Drug and chemical toxicology (New York, N.Y. 1978), 2018
Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti ...
Hemanta C Rao Tumu, Benedette J. Cuffari, Maria A. Pino, Jerzy Palus, Magdalena Pįętka-Ottlik, Blasé Billack   +5 more
openalex   +3 more sources

Evaluating the Treatment Patterns of Chlormethine/Mechlorethamine Gel in Patients With Stage I-IIA Mycosis Fungoides: By-time Reanalysis of a Randomized Controlled Phase 2 Study

Clinical Lymphoma, Myeloma & Leukemia, 2020
Larisa J. Geskin, Ellen J. Kim, James T. Angello, Youn H. Kim   +3 more
openalex   +2 more sources

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]

, 2001
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., Roddam, P.L., Roman, E., Cartwright, R.A., Morgan, G.J.   +9 more
core   +7 more sources

Advances in the treatment of mycoses fungoides and Sézary syndrome: a narrative update in skin-directed therapies and immune-based treatments

Frontiers in Immunology, 2023
Mycoses fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas that are often challenging to manage given the absence of reliably curative therapies, at times high symptom burden with significant detriment to quality of life, and need for
Robert Stuver, Shamir Geller
doaj   +1 more source