Results 101 to 110 of about 27,643 (268)

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

MeCP2 confers 5-fluorouracil resistance in gastric cancer via upregulating the NOX4/PKM2 pathway

Cancer Cell International, 2022
Background Increasing evidence suggests that aberrant methylation is involved in 5-fluorouracil (5-FU) resistance in gastric cancer (GC). Our previous work has identified that Methyl-CpG binding protein 2 (MeCP2) promotes GC progression by binding to the
Yannan Qin, Xiaoping Ma, Chen Guo, Shuang Cai, Hailin Ma, Lingyu Zhao   +5 more
doaj   +1 more source

La protéine MeCP2 : étude de son implication dans la réponse aux dommages à l'ADN et développement de nouveaux outils pour sa détection [PDF]

, 2010
Le syndrome de Rett est une maladie neurodéveloppementale progressive causée par des mutations du gène mecp2. Elle touche essentiellement les filles avec une fréquence d'environ 1/10000 naissances.
kaddoum, Lara
core  

Identification of MECP2 target genes and of proteins related to MECP2

, 2005
Rett Syndrom, eine schwere Form der geistigen Behinderung, wird durch Mutationen in dem X-chromosomalen Gen des Methyl-CpG bindenden Proteins 2 (MECP2) verursacht und kommt fast ausschließlich bei Mädchen vor. Mutationen in MECP2 wurden erstmals 1999 beschrieben, die molekularen Mechanismen, welche der Krankheit zugrunde liegen, sind bisher aber ...
openaire   +2 more sources

LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates

Structure
Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein involved in transcriptional regulation and chromatin remodeling. MeCP2 exists in two isoforms, MeCP2 E1 and E2, which share the same functional domains. Loss-of-function mutations in the MeCP2 gene are the main cause of Rett syndrome (RTT).
Lesire, Saskia, Lata, Rodrigo, Hoogvliets, Yannick, Herrebosch, Kune, van de Velde, Paulien, Speleers, Anouk, Christ, Frauke, Van Belle, Siska, Debyser, Zeger   +8 more
openaire   +2 more sources

Mecp2 fine-tunes quiescence exit by targeting nuclear receptors

eLife
Quiescence (G0) maintenance and exit are crucial for tissue homeostasis and regeneration in mammals. Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cultured cells and
Jun Yang, Shitian Zou, Zeyou Qiu, Mingqiang Lai, Qing Long, Huan Chen, Ping lin Lai, Sheng Zhang, Zhi Rao, Xiaoling Xie, Yan Gong, Anling Liu, Mangmang Li, Xiaochun Bai   +13 more
doaj   +1 more source

Shared molecular pathways in pediatric genetic epilepsies: Insights from a single‐center cohort of 80 patients

Epilepsia Open, EarlyView.
Abstract Objective Genetic epilepsies in childhood are highly heterogeneous, and approaches to identify shared biological mechanisms across distinct genetic etiologies remain limited. We aimed to investigate whether genes associated with pediatric genetic epilepsies in our heterogeneous cohort converge on common functional pathways.
Laura Hecher, Mathias Woidy, Franziska Plein, Tatjana Bierhals, Leonie von Elsner, Theresia Herget, Maja Hempel, Fanny Kortüm, Lev Grinstein, Julia V. Cramer, Jessika Johannsen, Jonas Denecke   +11 more
wiley   +1 more source

A central role for MeCP2 in the epigenetic repression of miR-200c during epithelial-to-mesenchymal transition of glioma

Journal of Experimental & Clinical Cancer Research, 2019
Background The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood.
Erbao Bian, Xueran Chen, Yadi Xu, Xinghu Ji, Meng Cheng, Hongliang Wang, Zhiyou Fang, Bing Zhao   +7 more
doaj   +1 more source

MECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males

BMC Medicine, 2023
Background Germline mosaicisms could be inherited to offspring, which considered as “de novo” in most cases. Paternal germline MECP2 mosaicism has been reported in fathers of girls with Rett syndrome (RTT) previously.
Yongxin Wen, Jiaping Wang, Qingping Zhang, Xiaoxu Yang, Liping Wei, Xinhua Bao   +5 more
doaj   +1 more source

Genetic developmental and epileptic encephalopathies in adulthood: Gaps in evidence and care

Epilepsia Open, EarlyView.
Abstract Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of the most severe epilepsies, characterized by seizure onset and neurodevelopmental delay in infancy or childhood, often with additional neurological and systemic comorbidities.
Alex M. Dudley, Peter Widdess‐Walsh, Christine Linehan, Danielle M. Andrade, Norman Delanty, Patrick B. Moloney   +5 more
wiley   +1 more source