Results 151 to 160 of about 27,643 (268)

MeCP2 and memory mechanisms [PDF]

Nature Reviews Neuroscience, 2006
Treating any disorder of the brain poses a special challenge owing to the difficulty of getting drugs across the blood–brain barrier. New work shows that implanting the brains of animal models with genetically engineered neural progenitor cells (NPCs) reduces some symptoms of Parkinson’s disease, and might benefit other neurodegenerative disorders ...
openaire   +1 more source

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells

Stem Cell Research & Therapy, 2018
Background Cellular aging may be associated with epigenetics. Methyl-CpG-binding protein 2 (MeCP2) and sirtuin 1 (SIRT1) are two important epigenetic factors.
Chunli Wang, Fei Wang, Zhen Li, Qing Cao, Liya Huang, Shuyan Chen   +5 more
doaj   +1 more source

Growth, Feeding and Nutrition in Rett Syndrome: Retrospective Audit of Twenty Years' Experience From an Australian Multidisciplinary Management Clinic

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim This study reviewed the nutritional status, feeding skills, safety, and management of patients with Rett syndrome during childhood and adolescence. Method Retrospective chart review of 103 females with classical Rett syndrome, aged ≤ 18 years, attending a Rett syndrome Multidisciplinary Management clinic in a tertiary hospital from 2000 to
Susan Thompson, Toni Bird, Gloria Tzannes, Carolyn Ellaway   +3 more
wiley   +1 more source

miR-22 targets Mecp2.

, 2014
A. Target scan showed that Mecp2 is predicted target of miR-22 with 4 potential binding sites on its 3′UTR. B. Western blot was performed in MSCs post transfection of microRNA scramble (miR-Scr), miR-22 mimic (100 nM) and miR-22 LNA inhibitor (50 nM) in ...
Yuliang Feng (394059), Wei Huang (36889), Muhammad Ashraf (133265), Xiyong Yu (133255), Mashhood Wani (523977)   +4 more
core   +1 more source

MeCP2 regulates activity-dependent transcriptional responses in olfactory sensory neurons [PDF]

, 2014
During postnatal development, neuronal activity controls the remodeling of initially imprecise neuronal connections through the regulation of gene expression.
Dunaway, Keith, Gong, Qizhi, Woods, Rima, Yasui, Dag H, Lee, Wooje, Lasalle, Janine M, Yun, Jung-Mi   +6 more
core   +1 more source

An increase in MECP2 dosage impairs neural tube formation

Neurobiology of Disease, 2014
Epigenetic mechanisms are fundamental for shaping the activity of the central nervous system (CNS). Methyl-CpG binding protein 2 (MECP2) acts as a bridge between methylated DNA and transcriptional effectors responsible for differentiation programs in ...
Paolo Petazzi, Naiara Akizu, Alejandra García, Conchi Estarás, Alexia Martínez de Paz, Manuel Rodríguez-Paredes, Marian A. Martínez-Balbás, Dori Huertas, Manel Esteller   +8 more
doaj   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Cross‐Regulation Between DNA Methylation and Circadian Clock Reprogramming in Ovarian Cancer: Mechanistic Insights, Biomarker Potential, and Therapeutic Implications

International Journal of Cancer, Volume 160, Issue 1, Page 7-23, 1 January 2027.
ABSTRACT Early diagnosis remains challenging, recurrence rates remain high, and platinum resistance frequently develops in ovarian cancer (OC), collectively representing major barriers to long‐term patient survival. DNA methylation (DNAm), as a relatively stable yet dynamically modifiable epigenetic signature, can capture alterations in tumor states ...
Min Xing, Chang Zhou, Yi Tang, Shuhui Xu, Shasha Zhou, Weiai Liu, Huiping Liu   +6 more
wiley   +1 more source

Extracellular Vesicles Enhance The Coupling of Neurogenesis and Angiogenesis and Neurological Recovery By Transfer of Micrornas After Stroke

Journal of Extracellular Biology, Volume 5, Issue 11, November 2026.
➢Extracellular vesicles (EVs) mediate the coupling of angiogenesis and neurogenesis. ➢Ischemic cerebral endothelial cell (CEC) derived EVs enhance neurogenesis. ➢EVs derived from either non‐ischemic or ischemic neural stem cells (NSCs) promote in vitro angiogenesis. ➢EV‐transmitted miRNAs regulate stroke‐induced neurogenesis and angiogenesis.
Xianshuang Liu, Wan Long Pan, Hua Teng, Xin Jiang, Yi Zhang, Xinli Wang, Amy Kemper, Michael Chopp, Zheng Gang Zhang   +8 more
wiley   +1 more source